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Details for Product No. ABIN151076

MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody

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Antigen
Synonyms ATLD, HNGS1, MRE11, MRE11B, Mre11, Mre11b, wu:faa63d12, zgc:64018
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151076
Quantity 50 µL
Price
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Immunogen Full length human Mre11 protein.
Specificity This antibody is specific for human Mre11. Species Reactivity: 100-142 recognizes both human and mouse. Other species have not been tested.
Cross-Reactivity Human, Mouse (Murine)
Purification Serum
Alternative Name MRE11
Background The hMre11-hRad50-NBS1 protein plays a central role in the human cellularDNA-Damage response, with recent studies indicating that these proteins help linkDNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This proteincomplex has been implicated in the activation of cell cycle-regulatory pathways, due tothe fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegenbreakdown syndrome (NBS), which is characterized by increased cancer incidence, cellcycle checkpoint defects, and ionizing radiation sensitivity.HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon aDNA damage-induced signaling pathway. However, hMre11 migrates to sites ofdamage while hRad51 does not localize at these sites. These findings are consistentwith the distinct role of these proteins in DNA repair. Alternate Names: anti-Ataxia-telangiectasia disorder-like antibody, anti-ATLD antibody, anti-MRE11aantibody, anti-MRE11b antibody.
Gene ID 4361, 17535
UniProt P49959
Application Notes Suggested working dilutions: immunofluorescence 1:200,Western Blot . Positive Controls: Hela whole cell lysate (NB 800-PC1)
Restrictions For Research Use only
Format Liquid
Buffer Preservative: Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Wang, Cortez, Yazdi et al.: "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures." in: Genes & development, Vol. 14, Issue 8, pp. 927-39, 2000 (PubMed).

Alternatives for antigen "MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A)", type "Antibodies"
Hosts (98), (12)
Reactivities (100), (60), (56), (28), (14), (4), (2), (2), (2), (2), (2), (1)
Applications (89), (52), (22), (20), (17), (12), (9), (4), (2), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (9), (5), (5), (4), (3), (3), (3), (1), (1), (1), (1)
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