MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody

Details for Product No. ABIN151076
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Antigen
Synonyms ATLD, HNGS1, MRE11, MRE11B, Mre11, Mre11b, wu:faa63d12, zgc:64018
Reactivity
Human
(100), (60), (57), (28), (14), (4), (2), (2), (2), (2), (2), (1)
Host
Rabbit
(100), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(89), (54), (21), (20), (18), (10), (7), (3), (2), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN151076
Quantity 50 µL
Price
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  • +1 888 205 9894 (TF)
Immunogen Full length human Mre11 protein.
Specificity This antibody is specific for human Mre11. Species Reactivity: 100-142 recognizes both human and mouse. Other species have not been tested.
Cross-Reactivity Human, Mouse (Murine)
Purification Serum
Alternative Name MRE11
Background The hMre11-hRad50-NBS1 protein plays a central role in the human cellularDNA-Damage response, with recent studies indicating that these proteins help linkDNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This proteincomplex has been implicated in the activation of cell cycle-regulatory pathways, due tothe fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegenbreakdown syndrome (NBS), which is characterized by increased cancer incidence, cellcycle checkpoint defects, and ionizing radiation sensitivity.HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon aDNA damage-induced signaling pathway. However, hMre11 migrates to sites ofdamage while hRad51 does not localize at these sites. These findings are consistentwith the distinct role of these proteins in DNA repair. Alternate Names: anti-Ataxia-telangiectasia disorder-like antibody, anti-ATLD antibody, anti-MRE11aantibody, anti-MRE11b antibody.
Gene ID 4361, 17535
UniProt P49959
Application Notes Suggested working dilutions: immunofluorescence 1:200,Western Blot . Positive Controls: Hela whole cell lysate (NB 800-PC1)
Restrictions For Research Use only
Format Liquid
Buffer Preservative: Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody Western Blot analysis of Mre11 on 50 ug of HeLa and MEF lysates, using ABIN151076
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody (2) MRE11 staining in the human epidermis detected with ABIN151076.
General Wang, Cortez, Yazdi et al.: "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures." in: Genes & development, Vol. 14, Issue 8, pp. 927-39, 2000 (PubMed).

Hosts (100), (10)
Reactivities (100), (60), (57), (28), (14), (4), (2), (2), (2), (2), (2), (1)
Applications (89), (54), (21), (20), (18), (10), (7), (3), (2), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (10), (5), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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