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Details for Product No. ABIN151077

Nibrin (NBN) antibody

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Synonyms AT-V1, AT-V2, ATV, NBS, NBS1, P95, Nbs1, NBN
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN151077
Quantity 50 µL
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Immunogen Human NBS1 protein (betwqeen residues 1-705). [Swiss-Prot# O60934].
Specificity This antibody is specific for human NBS1. Species Reactivity: ABIN151077 recognizes human NBS1 protein. This antibody does not work on mouseprotein in Western blot analysis. Other species have not been tested. Localization: Nuclear.
Cross-Reactivity Human
Purification Serum
Alternative Name Nibrin
Background The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50double-strand break complex. This protein complex has been implicated in Nijmegenbreakage syndrome, an autosomal recessive disorder marked by increased cancerincidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealinga direct molecular link between double-strand break repair and cell cycle checkpointfunctions. Alternate Names: anti-AT V1 antibody, anti-AT V2 antibody, anti-ATV antibody, anti-NBS antibody,anti-Nibrin antibody, anti-Nijmegen breakage syndrome antibody, anti-p95 antibody.
Gene ID 4683, 27354
UniProt O60934
Application Notes Positive Controls: TK6 and HeLa whole cell extract (NB 800-PC1)
Restrictions For Research Use only
Format Liquid
Buffer Whole antisera. Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Gatei, Young, Cerosaletti et al.: "ATM-dependent phosphorylation of nibrin in response to radiation exposure." in: Nature genetics, Vol. 25, Issue 1, pp. 115-9, 2000 (PubMed).

Wu, Petrini, Heine et al.: "Independence of R/M/N focus formation and the presence of intact BRCA1." in: Science (New York, N.Y.), Vol. 289, Issue 5476, pp. 11, 2000 (PubMed).

Paull, Rogakou, Yamazaki et al.: "A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage." in: Current biology : CB, Vol. 10, Issue 15, pp. 886-95, 2000 (PubMed).

Harfst, Cooper, Neubauer et al.: "Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome." in: Molecular immunology, Vol. 37, Issue 15, pp. 915-29, 2001 (PubMed).

Buscemi, Savio, Zannini et al.: "Chk2 activation dependence on Nbs1 after DNA damage." in: Molecular and cellular biology, Vol. 21, Issue 15, pp. 5214-22, 2001 (PubMed).

Huang, Dynan: "Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction." in: Nucleic acids research, Vol. 30, Issue 3, pp. 667-74, 2002 (PubMed).

Stracker, Carson, Weitzman: "Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex." in: Nature, Vol. 418, Issue 6895, pp. 348-52, 2002 (PubMed).

Goldberg, Stucki, Falck et al.: "MDC1 is required for the intra-S-phase DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 952-6, 2003 (PubMed).

Cerosaletti, Concannon: "Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21944-51, 2003 (PubMed).

Siwicki, Degerman, Chrzanowska et al.: "Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients." in: Experimental cell research, Vol. 287, Issue 1, pp. 178-89, 2003 (PubMed).

Alternatives for antigen "Nibrin (NBN)", type "Antibodies"
Hosts (174), (44)
Reactivities (214), (74), (50), (24), (24), (24)
Applications (177), (71), (56), (40), (30), (29), (19), (18), (5), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2)
Epitopes (46), (18), (16), (8), (7), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)