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DNA Repair Protein Homolog 1 (RAD51) antibody
Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|11 references available|
|Quantity||0.1 mg (2 mg/ml)|
|Price||Product not available in this region.|
|Immunogen||Fusion protein encoding full length (amino acids 1-338) of Rad51 expressed in E. coli.|
|Description||Rad51, a 37kDa protein, is the human homolog of E. coli RecA protein and a member ofthe RAD52 epistasis group in S. cerevisiae. In recent studies it has been reported thatBRCA1 interacts with Rad51 and disease-causing mutations have been found in theBRCA1 region necessary for BRCA1/Rad51 interaction, implying that this interaction isimportant for tumor suppression. BRCA2 and Rad51 have also been shown to interactby direct binding of the BRC repeats located within exon 11 of BRCA2. When theserepeats are deleted, the interaction is lost and cells become hypersensitive to the DNAdamage caused by methyl methanesulfonate (MMS). Alternate Names: anti-DNA repair protein RAD51 homolog 1 antibody, anti-E coli RecA homolog antibody,anti-HGNC:9817 antibody, anti-Homolog of E coli RecA antibody, anti-homolog of Scerevisiae RAD51 antibody, anti-HRAD51 antibody, anti-HsRad51 antibody,anti-HsT16930 antibody, anti-RAD51 S cerevisiae homolog antibody, anti-RAD51Aantibody, anti-RECA antibody, anti-RecA like protein antibody, anti-recombinationprotein A antibody.|
|Specificity||This antibody is specific for Rad51. Species Reactivity: ABIN151080 reacts with human Rad51.|
|Application Notes||Positive Controls: T24 bladder carcinoma cells and recombinant fusion protein.|
|Buffer||PBS [pH7.4]. Preservative: None|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Restrictions||For Research Use only|
|anti-DNA Repair Protein Homolog 1 (RAD51) antibody|
Shinohara, Ogawa, Matsuda et al.: "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA." in: Nature genetics, Vol. 4, Issue 3, pp. 239-43, 1993 (PubMed).
Scully, Chen, Plug et al.: "Association of BRCA1 with Rad51 in mitotic and meiotic cells." in: Cell, Vol. 88, Issue 2, pp. 265-75, 1997 (PubMed).
Chen, Chen, Chen et al.: "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5287-92, 1998 (PubMed).
Masson, Davies, Hajibagheri et al.: "The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51." in: The EMBO journal, Vol. 18, Issue 22, pp. 6552-60, 2000 (PubMed).
Masson, Tarsounas, Stasiak et al.: "Identification and purification of two distinct complexes containing the five RAD51 paralogs." in: Genes & development, Vol. 15, Issue 24, pp. 3296-307, 2001 (PubMed).
French, Masson, Griffin et al.: "Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19322-30, 2002 (PubMed).
Tarsounas, Davies, West: "BRCA2-dependent and independent formation of RAD51 nuclear foci." in: Oncogene, Vol. 22, Issue 8, pp. 1115-23, 2003 (PubMed).
Kao, McKenna, Guenther et al.: "Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response." in: The Journal of cell biology, Vol. 160, Issue 7, pp. 1017-27, 2003 (PubMed).
Warren, Lord, Masabanda et al.: "Phenotypic effects of heterozygosity for a BRCA2 mutation." in: Human molecular genetics, Vol. 12, Issue 20, pp. 2645-56, 2003 (PubMed).
Shim, Schmutte, Tombline et al.: "hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 30385-94, 2004 (PubMed).
Stewart, Stankovic, Byrd et al.: "RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 43, pp. 16910-5, 2007 (PubMed).