RAD50 Homolog (S. Cerevisiae) (RAD50) antibody

Details for Product No. ABIN151081
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Antigen
Synonyms NBSLD, RAD502, hRad50, Mrell, Rad50l, 6339, CG6339, Dmel\\CG6339, Dmrad50, RAD50, Rad50, ATRAD50, DNA REPAIR-RECOMBINATION PROTEIN, F22D22.28, F22D22_28, SPAP4C9.01c
Reactivity
Human
(45), (16), (7), (3), (1)
Host
Rabbit
(46), (7), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(55), (22), (16), (8), (6), (5), (4), (2), (2)
Pubmed 2 references available
Catalog no. ABIN151081
Quantity 0.1 mL
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Immunogen Human Rad50 zinc hook region (amino acids 628-787) expressed in E. coli.
Specificity This antibody is specific for human Rad50. Species Reactivity: Reacts with human Rad50. Other species have not been tested. Localization: Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within thenucleus of damaged cells.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Serum
Alternative Name RAD50
Background Rad50, a 153kDa protein, is associated with Mre11 and Nbs1 (Nibrin or p95) to form amultiprotein complex involved in the double strand break repair process. Rad50 is amember of the family of structural maintenance of chromosome (SMC) proteins. Members of this family share similar structures consisting of globular N- and C-terminiseparated by a coiled-coil domain. At the base of the coiled-coil region is a zinc bindingmotif, the zinc hook. The zinc hook mediates Rad50 dimerization through the linkage oftwo Rad50 coiled-coil tails. Alternate Names: anti-hRad50 antibody, anti-hsRAD50 antibody, anti-Mrell antibody, anti-RAD50 2antibody, anti-RAD50 homolog (S cerevisiae) antibody, anti-RAD50 PEN antibody,anti-Rad50l antibody, anti-Truncated RAD50 protein antibody.
Gene ID 10111
UniProt Q92878
Application Notes Suggested working dilutions: immunoprecipitation 1-5ul ,Western Blot 1:1000-1:10000
Restrictions For Research Use only
Format Liquid
Buffer 0.1 ml of whole rabbit antisera. It does not contain any preservative.
Preservative Without preservative
Storage 4 °C
Supplier Images
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody Detection of Rad50 using ABIN151081.Lane 1: 25 ng purified hMre11-hRad50 complexLane 2: 25 ug crude HeLa extract
General Carney, Maser, Olivares et al.: "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response." in: Cell, Vol. 93, Issue 3, pp. 477-86, 1998 (PubMed).

Cahill, Carney: "Dimerization of the Rad50 protein is independent of the conserved hook domain." in: Mutagenesis, Vol. 22, Issue 4, pp. 269-74, 2007 (PubMed).

Hosts (46), (7), (2)
Reactivities (45), (16), (7), (3), (1)
Applications (55), (22), (16), (8), (6), (5), (4), (2), (2)
Conjugates (2)
Epitopes (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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