Flap Structure-Specific Endonuclease 1 (FEN1) (AA 1-380) antibody

Details for Product No. ABIN151083
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Antigen
Synonyms FEN-1, FEN1, AW538437, MF1, RAD2, cb879, fen-1, fen1, mf1, rad2, xFEN1a
Epitope
AA 1-380
(7), (6), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(75), (35), (32), (14), (13), (12), (1), (1), (1), (1)
Host
Mouse
(63), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
(64), (19), (16), (16), (10), (9), (9), (8), (3), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN151083
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Immunogen Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.
Clone 4E7
Isotype IgG1 kappa
Specificity This is specific for FEN-1.
Purification Protein G purified
Alternative Name FEN1 / RAD2
Background FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 kDa protein thatfunctions as an endonuclease that cleaves branched DNA structures containingsingle-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1endonuclease and exonuclease activities are stimulated by an association withproliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to haveimportant roles in DNA replication and repair and is required in cell-free DNA replicationsystems. Alternate Names: anti-Flap endonuclease 1 antibody, anti-flap structure specific endonuclease 1 antibody,anti-Maturation factor 1 antibody, anti-MF1 antibody, anti-RAD2 (S. pombe) homologantibody, anti- fen-1 antibody.
Gene Symbol: FEN1
Gene ID 2237
Application Notes Recommended dilutions: Flow Cytometry 1:10-1:1000, Immunocytochemistry/Immunofluorescence 1:10-1:2000, Western Blot 1-5 µg/mL
Restrictions For Research Use only
Buffer PBS [pH 7.4]
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Qiu, Li, Frank et al.: "Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4901-8, 2001 (PubMed).

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