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Flap Structure-Specific Endonuclease 1 (FEN1) antibody

Antigen

Flap Structure-Specific Endonuclease 1 (FEN1)
Synonyms MF1, RAD2, FEN-1, FEN1
Clonality Monoclonal (4E7)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
1 reference available
Catalog no. ABIN151083
Quantity 0.1 mg
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives back to top

Alternative name FEN1 / RAD2
Gene ID 2237
Immunogen Recombinant human FEN-1 protein encoding amino acids 1-380 purified frombaculovirus-infected Sf-9 cells.
Cross-Reactivity Human
Isotype IgG1
Clone 4E7
Description FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 kDa protein thatfunctions as an endonuclease that cleaves branched DNA structures containingsingle-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1endonuclease and exonuclease activities are stimulated by an association withproliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to haveimportant roles in DNA replication and repair and is required in cell-free DNA replicationsystems. Alternate Names: anti-Flap endonuclease 1 antibody, anti-flap structure specific endonuclease 1 antibody,anti-Maturation factor 1 antibody, anti-MF1 antibody, anti-RAD2 (S. pombe) homologantibody, anti- fen-1 antibody.
Specificity This antibody is specific for FEN-1. Species Reactivity: ABIN151083 reacts with human FEN-1.

Application Details
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Application Notes Western Blot 1-5 mg/ml,Positive Controls: MCF-7 cells, recombinant fusion protein.
Purification Purified
Buffer PBS [pH 7.4]
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Qiu, Li, Frank et al.: "Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4901-8, 2001 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Flap Structure-Specific Endonuclease 1 (FEN1)", type "Antibodies"
Hosts Rabbit (59), Mouse (7)
Reactivities Human (65), Rat (Rattus) (41), Mouse (Murine) (40), Cow (Bovine) (34), Dog (Canine) (33), Horse (Equine) (31), Pig (Porcine) (31), Sheep (Ovine) (19), Rabbit (18), Chicken (15), Cat (Feline) (1), Xenopus laevis (1), Zebrafish (1)
Applications Western Blotting (WB) (40), Immunofluorescence (IF) (29), ELISA (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunoprecipitation (IP) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (3), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Dot Blot (Dot) (1), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes AA 1-380 (3), N-Term (3), Internal Region (2), C-Term (1), Center (1)