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Details for Product No. ABIN151083

Flap Structure-Specific Endonuclease 1 (FEN1) antibody

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Synonyms MF1, RAD2, FEN-1, AW538437, cb879, fen-1, fen1, mf1, rad2, xFEN1a, FEN1
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151083
Quantity 0.1 mg
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Immunogen Recombinant human FEN-1 protein encoding amino acids 1-380 purified frombaculovirus-infected Sf-9 cells.
Clone 4E7
Isotype IgG1
Specificity This antibody is specific for FEN-1. Species Reactivity: ABIN151083 reacts with human FEN-1.
Cross-Reactivity Human
Purification Purified
Alternative Name FEN1 / RAD2
Background FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 kDa protein thatfunctions as an endonuclease that cleaves branched DNA structures containingsingle-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1endonuclease and exonuclease activities are stimulated by an association withproliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to haveimportant roles in DNA replication and repair and is required in cell-free DNA replicationsystems. Alternate Names: anti-Flap endonuclease 1 antibody, anti-flap structure specific endonuclease 1 antibody,anti-Maturation factor 1 antibody, anti-MF1 antibody, anti-RAD2 (S. pombe) homologantibody, anti- fen-1 antibody.
Gene ID 2237
Application Notes Western Blot 1-5 mg/ml,Positive Controls: MCF-7 cells, recombinant fusion protein.
Restrictions For Research Use only
Buffer PBS [pH 7.4]
Storage -20 °C
Qiu, Li, Frank et al.: "Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4901-8, 2001 (PubMed).

Alternatives for antigen "Flap Structure-Specific Endonuclease 1 (FEN1)", type "Antibodies"
Hosts (54), (16)
Reactivities (69), (30), (29), (14), (13), (12), (1), (1), (1), (1)
Applications (59), (17), (10), (10), (9), (7), (5), (4), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (4), (3), (2), (2), (2), (1)