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Details for Product No. ABIN151253

RAD17 Homolog (S. Pombe) (RAD17) antibody

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Synonyms CCYC, HRAD17, R24L, RAD17SP, RAD24, 9430035O09Rik, MmRad24, K2A18.21, K2A18_21, RAD17, RADIATION SENSITIVE 17, zgc:56502, zgc:77779, xrad1, RAD1, DKFZp459H1127, zgc:91969
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151253
Quantity 0.1 mg
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Immunogen Synthetic peptide made to a N-terminal region of human RAD17.
Specificity Reacts with residues 2-15 [NQVTDWVDPSFDDF] of the human RAD17 protein. Species Reactivity: Human. Not tested in other species.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name RAD17
Background Signals originating from damaged DNA activate checkpoint pathways and target themitotic apparatus via a number a distinct mechanisms. These checkpoints link damageto DNA with the components of the cell cycle through signal transduction systems.In mammals, five genes have been identified as components of DNA damage-inducedcheckpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. Whenoverexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulationof G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpointpathway.(1). Alternate Names: anti-Cell cycle checkpoint protein antibody, anti-HRAD17 antibody, anti-R24L antibody,anti-RAD17 homolog antibody, anti-Rad17 like protein antibody, anti-RAD17Spantibody, anti-Rad24 antibody, anti-RF C activator 1 homolog antibody.
Gene ID 5884
Application Notes Suggested working dilutions: Western Blot 1:500 to 1:1000
Restrictions For Research Use only
Concentration 1.0 mg/ml
Buffer PBS. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage 4 °C
Li, Peterson, Kanter-Smoler et al.: "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation." in: Oncogene, Vol. 18, Issue 9, pp. 1689-99, 1999 (PubMed).

Bao, Tibbetts, Brumbaugh et al.: "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses." in: Nature, Vol. 411, Issue 6840, pp. 969-74, 2001 (PubMed).

Alternatives for antigen "RAD17 Homolog (S. Pombe) (RAD17)", type "Antibodies"
Hosts (95), (10), (7)
Reactivities (94), (53), (32), (15), (13), (12), (5), (2), (2), (2), (1), (1)
Applications (94), (30), (20), (14), (12), (8), (5), (4), (3), (3), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (26), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)