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RAD17 Homolog (S. Pombe) (RAD17) antibody

Antigen

RAD17 Homolog (S. Pombe) (RAD17)
Synonyms CCYC, R24L, RAD24, HRAD17, RAD17SP, FLJ41520, MGC77779, zgc:56502, zgc:77779, RAD1, rad1, RAD17, DKFZp459H1127, zgc:91969, MGC140462
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN151253
Quantity 0.1 mg  (1.0 mg/ml)  (Variants)
Price Product not available in this region.
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anti-RAD17 Homolog (S. Pombe) (RAD17) antibody

Additional Information
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Alternative name RAD17
Gene ID 5884
Immunogen Synthetic peptide made to a N-terminal region of human RAD17.
Cross-Reactivity Human
Description Signals originating from damaged DNA activate checkpoint pathways and target themitotic apparatus via a number a distinct mechanisms. These checkpoints link damageto DNA with the components of the cell cycle through signal transduction systems.In mammals, five genes have been identified as components of DNA damage-inducedcheckpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. Whenoverexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulationof G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpointpathway.(1). Alternate Names: anti-Cell cycle checkpoint protein antibody, anti-HRAD17 antibody, anti-R24L antibody,anti-RAD17 homolog antibody, anti-Rad17 like protein antibody, anti-RAD17Spantibody, anti-Rad24 antibody, anti-RF C activator 1 homolog antibody.
Specificity Reacts with residues 2-15 [NQVTDWVDPSFDDF] of the human RAD17 protein. Species Reactivity: Human. Not tested in other species.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:500 to 1:1000
Concentration 1.0 mg/ml
Purification Aff - Purified
Buffer PBS. Preservative: 0.01% sodium azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Restrictions For Research Use only

Publications
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Li, Peterson, Kanter-Smoler et al.: "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation." in: Oncogene, Vol. 18, Issue 9, pp. 1689-99, 1999 (PubMed).

Bao, Tibbetts, Brumbaugh et al.: "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses." in: Nature, Vol. 411, Issue 6840, pp. 969-74, 2001 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "RAD17 Homolog (S. Pombe) (RAD17)", type "Antibodies"
Hosts Rabbit (54), Goat (5), Mouse (3)
Reactivities Human (51), Mouse (Murine) (20), Rat (Rattus) (11), Cow (Bovine) (3), Horse (Equine) (2), Monkey (2), Yeast (Saccharomyces cerevisiae) (2), Dog (Canine) (1), Yeast (1)
Applications Western Blotting (WB) (56), ELISA (17), Immunofluorescence (IF) (13), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunocytochemistry (ICC) (4), Flow Cytometry (FACS) (2), Immunoprecipitation (IP) (2)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), PE,Cy5.5 (1)
Epitopes pSer645 (9), AA 2-15 (4), N-Term (4), C-Term (2), AA 1-200 (1), AA 10-23 (1), Center (1), pSer647 (1), pSer656 (1), pSer71 (1)