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BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody

Antigen

BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1)
Synonyms OF, BACH1, FANCJ, FLJ90232, MGC126521, MGC126523, Bach1, 3110009N10Rik, 8030460J03Rik, MGC68622, BRIP1, fancj, si:ch211-158l18.1
Clonality Monoclonal (Pp15-IB4)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN151393
Quantity 0.1 ml  (Variants)
Price Product not available in this region.
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anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody

Additional Information
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Alternative name BRIP1 / FANCJ
Gene ID 83990
Immunogen Partial Brip1 protein peptide.
Cross-Reactivity Human
Format Ascites
Isotype IgG1
Clone Pp15-IB4
Description BRIP1 (also called BACH1) is a helicase that interacts with the BRCT domain of BRCA1and has a role in BRCA1-dependent DNA repair and checkpoint. BRIP1 has recentlybeen found to be defective in Fanconi anemia complementation group J. BRIP1/FANCJhas a function in the Fanconi anemia pathway that is independent of BRCA1 anddownstream of FANCD2 activation. (1-4). Alternate Names: anti-FANCJ protein antibody, anti-BACH 1 antibody, anti-BACH1 BRIP1 antibody,anti-BRIP 1 antibod, anti-BRAC 1 Associated C Terminal Helicase 1 antibody,anti-BRCA 1 Interacting Protein 1 antibody, anti- Fanconi anemia group J protein.
Specificity This antibody is specific for Brip1 /FANCJ. Species Reactivity: Human. Other species have not been tested. Localization: Nuclear.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:500-1:1000. Positive Controls: HeLa whole and nuclear extracts, Raji whole extracts
Purification Ascites
Buffer 100 ul of mouse ascites [7.4 mg/ml], containing 0.02% Sodium Azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Restrictions For Research Use only

Publications
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Cantor, Bell, Ganesan et al.: "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function." in: Cell, Vol. 105, Issue 1, pp. 149-60, 2001 (PubMed).

Cannavo, Gerrits, Marra et al.: "Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2976-86, 2007 (PubMed).

Kim, Kee, Gurtan et al.: "Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24." in: Blood, Vol. 111, Issue 10, pp. 5215-22, 2008 (PubMed).

Alternatives
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Alternatives for antigen "BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1)", type "Antibodies"
Hosts Rabbit (34), Mouse (8), Chicken (1)
Reactivities Human (43), Mouse (Murine) (24), Rat (Rattus) (24), Chicken (19), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (19), Pig (Porcine) (19)
Applications Immunofluorescence (IF) (21), Western Blotting (WB) (19), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes C-Term (4), pSer990 (4), AA 1233-1249 (2), N-Term (2), AA 92-104 (1), pThr401 (1)