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Cadherin pan antibody (Cadherin Pan) (C-Term)

Details for Product anti-Cadherin Pan Antibody No. ABIN151404, Supplier: Login to see
Antigen
Epitope
C-Term, N-Term
4
Reactivity
Cow (Bovine)
2
2
Host
Mouse
4
Clonality (Clone)
Monoclonal ()
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Microarray (MA), Western Blotting (WB)
4
2
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Immunogen Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.
Clone CH-19
Isotype IgG1
Specificity Monoclonal Anti-Pan Cadherin antibody reacts extensively with all known members of the cadherin famil
Cross-Reactivity (Details) May react with Hamster.
Purification Ascites
Alternative Name Cadherin (pan)
Background Cadherins are members of a multigene family of single chain glycoprotein receptorsmediating Ca2+-dependent cell-cell adhesion.1,2,3 The N-terminal part of thesemolecules is exposed on the external cell surface and contains the putative homophilicbinding sites. This is followed by a typical single transmembrane sequence and usuallya cytoplasmic C-terminal tail which mediates interaction with the microfilament systemthrough molecules such as catenins, plakoglobin, vinculin, and.
Gene Symbol: CDH1
Gene ID 999, 83502
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Pathways
Application Notes The antibody reacts using frozen sections, protease-digested, formalin-fixed paraffin-embedded, Bouin's-fixed and acetone-fixed tissue sections.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:500, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Paraffin 1:500, Microarray, Western Blot 1:100-1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-Cadherin pan antibody (Cadherin Pan) (C-Term) (ABIN151404) Monoclonal Anti-Pan Cadherin antibody produced in mouse
Background publications Orthmann-Murphy, Salsano, Abrams et al.: "Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations." in: Brain : a journal of neurology, Vol. 132, Issue Pt 2, pp. 426-38, 2009 (PubMed).

Takeichi: "Cadherins: a molecular family important in selective cell-cell adhesion." in: Annual review of biochemistry, Vol. 59, pp. 237-52, 1990 (PubMed).