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Details for Product No. ABIN151404

Cadherin Pan antibody

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Antigen
Reactivity
»Alternatives Cow (Bovine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151404
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide: DYDYLNDWGPRFKKLADMYGGGDD conjugated to KLH,corresponding to 24 amino acids 889-912 of Chicken N-Cadherin (cdh2).
Clone CH-19
Isotype IgG1
Specificity Reacts with all cadherins. The cadherins migrate in the molecular weight range of 125 to140 kDa and are tissue dependent. Species Reactivity: Cross-reacts with Human, Mouse, Rat, Cat, Chicken, Cow, Dog, Goat, Guinea Pig,Hamster, Pig, Psammoys (sand rat), Rabbit, Sheep, Snake and Xenopus. Not yet testedin other species. Localization: Cell membrane.
Cross-Reactivity Cow (Bovine), Dog (Canine), Chicken, Cat (Feline), Guinea Pig, Hamster, Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine), Xenopus laevis
Purification Ascites
Alternative Name Cadherin (pan)
Background Cadherins are members of a multigene family of single chain glycoprotein receptorsmediating Ca2+-dependent cell-cell adhesion.1,2,3 The N-terminal part of thesemolecules is exposed on the external cell surface and contains the putative homophilicbinding sites. This is followed by a typical single transmembrane sequence and usuallya cytoplasmic C-terminal tail which mediates interaction with the microfilament systemthrough molecules such as catenins, plakoglobin, vinculin, and.
Gene ID 1000, 83502
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Suggested working dilutions: Western Blot 1/1000,Immunohistochemistry-Paraffin 1/500,Immunohistochemistry-Frozen
Restrictions For Research Use only
Format Liquid
Concentration 6.6 mg/ml
Buffer Ascitic fluid. Preservative: Sodium azide.
Preservative Sodium azide
Storage 4 °C
Takeichi: "Cadherins: a molecular family important in selective cell-cell adhesion." in: Annual review of biochemistry, Vol. 59, pp. 237-52, 1990 (PubMed).

Orthmann-Murphy, Salsano, Abrams et al.: "Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations." in: Brain : a journal of neurology, Vol. 132, Issue Pt 2, pp. 426-38, 2009 (PubMed).

Alternatives for antigen "Cadherin Pan", type "Antibodies"
Hosts (12), (3)
Reactivities (11), (7), (7), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (10), (7), (4), (4), (2), (2), (1), (1), (1)
Epitopes (2)
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