Wolfram Syndrome 1 (WFS1) antibody

Details for Product No. ABIN151416
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Antigen
Synonyms CG4917, Dmel\\CG4917, GB15257, WFS1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(26), (24), (23), (12), (12)
Host
Rabbit
(28), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(22), (13), (10), (9), (8), (6), (6), (3), (3), (3)
Pubmed 2 references available
Catalog no. ABIN151416
Quantity 0.1 mL
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Immunogen A 110 amino acid region of the N-terminal region of thehuman protein.
Specificity Species Reactivity: ABIN151416 can be used to detect human, rat and mouse WFS1 protein. Localization: Endoplasmic reticulum.
Purification Serum
Alternative Name Wolframin / WFS1
Background WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum(ER) in the pancreas. It is normally up-regulated during insulin secretion, whereasinactivation of the protein can cause ER stress. Chronic ER stress is a majorinvolvement in Wolfram syndrome. Alternate Names: anti-Wolfram antibody, anti-wolfram syndrome 1 antibody. Related Diseases: Diabetes, Wolfram Syndrome, Neurodegenerative Disease
Gene ID 7466, 83725
UniProt O76024
Application Notes Suggested working dilutions: immunofluorescence 1:200,immunoprecipitation 2 ul,Western Blot 1:500-1:2000,Immunohistochemistry-Frozen 1:1000. Positive Controls: See notes.
Restrictions For Research Use only
Format Liquid
Buffer 0.1 ml of whole antisera containing 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Wolfram Syndrome 1 (WFS1) antibody Detection of WFS1 in insulinoma cells in WB using ABIN151416.
anti-Wolfram Syndrome 1 (WFS1) antibody (2) Immunoprecipitation of WFS1 using ABIN151416. Precipitated lysate is INS-1.
General Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Fonseca, Fukuma, Lipson et al.: "WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39609-15, 2005 (PubMed).

Hosts (28), (2), (2)
Reactivities (26), (24), (23), (12), (12)
Applications (22), (13), (10), (9), (8), (6), (6), (3), (3), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2), (1)
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