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Wolfram Syndrome 1 (Wolframin) (WFS1) antibody

Antigen

Wolfram Syndrome 1 (Wolframin) (WFS1)
Synonyms WFS, WFRS, FLJ51211, WOLFRAMIN, DmelCG4917, CG4917, GB15257, WFS1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
2 references available
Catalog no. ABIN151416
Quantity 0.1 ml  (Variants)
Price Product not available in this region.
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anti-Wolfram Syndrome 1 (Wolframin) (WFS1) antibody

anti-Wolfram Syndrome 1 (Wolframin) (WFS1) antibody (2)

Additional Information
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Alternative name Wolframin / WFS1
Gene ID 7466, 83725
UniProt O76024
Immunogen A 110 amino acid region of the N-terminal region of thehuman protein.
Format Serum
Description WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum(ER) in the pancreas. It is normally up-regulated during insulin secretion, whereasinactivation of the protein can cause ER stress. Chronic ER stress is a majorinvolvement in Wolfram syndrome. Alternate Names: anti-Wolfram antibody, anti-wolfram syndrome 1 antibody. Related Diseases: Diabetes, Wolfram Syndrome, Neurodegenerative Disease
Specificity Species Reactivity: ABIN151416 can be used to detect human, rat and mouse WFS1 protein. Localization: Endoplasmic reticulum.

Application Details
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Application Notes Suggested working dilutions: immunofluorescence 1:200,immunoprecipitation 2 ul,Western Blot 1:500-1:2000,Immunohistochemistry-Frozen 1:1000. Positive Controls: See notes.
Buffer 0.1 ml of whole antisera containing 0.1% sodium azide.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
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Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Fonseca, Fukuma, Lipson et al.: "WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39609-15, 2005 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Wolfram Syndrome 1 (Wolframin) (WFS1)", type "Antibodies"
Hosts Rabbit (31)
Reactivities Human (28), Mouse (Murine) (27), Rat (Rattus) (26), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (18), Cat (Feline) (1), Chicken (1)
Applications Immunofluorescence (IF) (18), Western Blotting (WB) (16), ELISA (11), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes N-Term (4), AA 100-200 (1)