Drebrin 1 (DBN1) antibody

Details for Product No. ABIN151450
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Antigen
Synonyms LOC733967, D0S117E, DBN1
Reactivity
Cow (Bovine), Chicken, Cat (Feline), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(44), (20), (19), (17), (15), (15), (11)
Host
Mouse
(21), (20), (8), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(35), (16), (15), (12), (12), (10), (9), (9), (6), (5)
Pubmed 4 references available
Quantity 0.05 mg
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Catalog No. ABIN151450
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Immunogen Chicken Drebrin E protein.
Clone M2F6
Isotype IgG
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein A purified
Alternative Name Drebrin
Background Drebrins are actin-binding proteins, that are developmentally regulated in the process ofneuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated byalternative RNA splicing from a single debrin gene in the chicken brain. The expressionpattern of each isoform is regulated spatially and temporally in the developing brain. Ithas been suggested that debrin is one of the intracellular regulators of the neuronalmorphogenesis (4). Debrin has also been detected in other kinds of non-neuronalhuman and bovine tissue but its exact role is unknown. Alternate Names: anti-D0S117E antibody, anti-DBN 1 antibody, anti-DBN1 antibody, anti-Developmentallyregulated brain protein antibody, anti-DKFZp434D064 antibody, anti-Drebrin 1 antibody, anti-Drebrin E antibody, anti-Drebrin1 antibody, DrebrinE antibody.
Gene Symbol: DBN1
Gene ID 1627, 56320, 81653
Research Area Cancer, Cytoskeleton, Microfilaments, Alzheimer's Disease
Application Notes In Western Blot a 110kDa band is seen due to large amounts of negative residues (predicted MW 71 kDa). This antibody has been reported in the literature to work in Immunohistochemistry (PMID: 1314351)
Recommended dilutions: Immunohistochemistry 10 µg/mL, Immunohistochemistry-Paraffin 10 µg/mL, Western Blot 10 µg/mL
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS with 50 % glycerol [pH 7.2]
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Drebrin 1 (DBN1) antibody Western Blot: Drebrin Antibody (M2F6) [ABIN151450] - Western blot analysis of mouse brain tissue extract probed with ABIN151450
General Kojima, Kato, Shirao et al.: "Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs." in: Brain research, Vol. 464, Issue 3, pp. 207-15, 1989 (PubMed).

Shirao: "The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review." in: Journal of biochemistry, Vol. 117, Issue 2, pp. 231-6, 1995 (PubMed).

Peitsch, Grund, Kuhn et al.: "Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells." in: European journal of cell biology, Vol. 78, Issue 11, pp. 767-78, 2000 (PubMed).

Maezawa, Nivison, Montine et al.: "Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 6, pp. 797-9, 2006 (PubMed).

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