CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) antibody

Details for Product No. ABIN151496
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Synonyms Boris, OTTMUSG00000016680, BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2, CTCFL, im:7152666, CTCF, xctcf
(27), (19), (16), (12), (12), (12), (1)
(30), (2)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), ELISA
(23), (10), (8), (5), (3), (3), (1)
Pubmed 2 references available
Catalog no. ABIN151496
Quantity 0.1 mg
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Immunogen Synthetic peptide (Human) - amino acids 9-26 of human BORIS.
Specificity Species Reactivity: Cross-reacts with Human. Expected to cross react with chimpanzee. May react withmouse, dog and rat sources based on sequence homology. Not yet tested in otherspecies. Localization: Nuclear and cytoplasmic.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name CTCFL / BORIS
Background BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-bindingfactor-like protein, is normally only expressed in the testis and expressed in a mutuallyexclusive manner with CTCF during male germ cell development. However, previousstudies have shown that BORIS is abnormally activated in a wide range of humancancers. Expression of BORIS in normally BORIS-negative cells promotes cell growththat may lead to transformation. BORIS maps to the cancer-associated amplificationregion thought to contain an oncogene or dominant-immortalizing gene. BORIS is acandidate protein for the epigenetic reprogramming factor acting in the male germ line.BORIS is found in both the nucleus and cytoplasm. Alternate Names: anti-Brother Of The Regulator Of Imprinted Sites antibody.
Gene ID 140690
Application Notes Suggested working dilutions: Western Blot 1:200 - 1:2000. Positive Controls: Human prostate. Also found in cancerous cell lines.
Restrictions For Research Use only
Concentration 1.28 mg/ml
Buffer 0.02M Potassium phosphate, 0.15 M Sodium chloride pH7.2. Preservative: Sodium Azide.
Preservative Sodium azide
Storage -20 °C
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anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) antibody anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) antibody
General Klenova, Morse, Ohlsson et al.: "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer." in: Seminars in cancer biology, Vol. 12, Issue 5, pp. 399-414, 2002 (PubMed).

Monk, Hitchins, Hawes: "Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development." in: Molecular human reproduction, Vol. 14, Issue 6, pp. 347-55, 2008 (PubMed).

Hosts (30), (2)
Reactivities (27), (19), (16), (12), (12), (12), (1)
Applications (23), (10), (8), (5), (3), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (4), (3), (1), (1)
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