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CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) antibody

Antigen

CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL)
Synonyms CTCFL, Boris, RP23-44L6.1, OTTMUSG00000016680, BORIS, CT27, CTCF-T, MGC163358, dJ579F20.2, AW108038, CTCF, im:7152666, xctcf
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Catalog no. ABIN151496
Quantity 0.1 mg  (1.28 mg/ml)
Price Product not available in this region.
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anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) antibody

Additional Information
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Alternative name CTCFL / BORIS
Gene ID 140690
Immunogen Synthetic peptide (Human) - amino acids 9-26 of human BORIS.
Cross-Reactivity Human
Description BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-bindingfactor-like protein, is normally only expressed in the testis and expressed in a mutuallyexclusive manner with CTCF during male germ cell development. However, previousstudies have shown that BORIS is abnormally activated in a wide range of humancancers. Expression of BORIS in normally BORIS-negative cells promotes cell growththat may lead to transformation. BORIS maps to the cancer-associated amplificationregion thought to contain an oncogene or dominant-immortalizing gene. BORIS is acandidate protein for the epigenetic reprogramming factor acting in the male germ line.BORIS is found in both the nucleus and cytoplasm. Alternate Names: anti-Brother Of The Regulator Of Imprinted Sites antibody.
Specificity Species Reactivity: Cross-reacts with Human. Expected to cross react with chimpanzee. May react withmouse, dog and rat sources based on sequence homology. Not yet tested in otherspecies. Localization: Nuclear and cytoplasmic.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:200 - 1:2000. Positive Controls: Human prostate. Also found in cancerous cell lines.
Concentration 1.28 mg/ml
Purification Aff - Purified
Buffer 0.02M Potassium phosphate, 0.15 M Sodium chloride pH7.2. Preservative: Sodium Azide.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
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Klenova, Morse, Ohlsson et al.: "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer." in: Seminars in cancer biology, Vol. 12, Issue 5, pp. 399-414, 2002 (PubMed).

Monk, Hitchins, Hawes: "Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development." in: Molecular human reproduction, Vol. 14, Issue 6, pp. 347-55, 2008 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL)", type "Antibodies"
Hosts Rabbit (34), Mouse (3), Rat (1)
Reactivities Human (36), Rat (Rattus) (25), Mouse (Murine) (24), Cow (Bovine) (20), Dog (Canine) (19), Pig (Porcine) (19), Horse (Equine) (18), Cat (Feline) (1), Chicken (1), Chimpanzee (1), Rabbit (1)
Applications Western Blotting (WB) (23), Immunofluorescence (IF) (21), ELISA (14), Immunohistochemistry (IHC) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes AA 9-26 (2), N-Term (2)