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Details for Product No. ABIN151518

Structural Maintenance of Chromosomes 1A (SMC1A) (pSer957) antibody

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Antigen
Synonyms CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, SMC-1A, 5830426I24Rik, Sb1.8, Smc1, Smc1alpha, Smc1l1, Smcb, mKIAA0178, smc1, smc1a, smc1l1, xSMC1, zgc:76902, im:7158706, SMC1L2, NV15570
Epitope
»Alternatives pSer957
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Proximity Ligation Assay (PLA), Western Blotting (WB)
Pubmed 12 references available
Catalog no. ABIN151518
Quantity 0.1 mL
Price
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, whichrepresented a portion of human Structural Maintenance of Chromosomes 1 (GeneID8243) around serine 957 according to the numbering given in entry NP_006297.2.
Specificity ABIN151518 reacts with human SMC1 phosphoSerine 957Phosphorylated:Ser957. Species Reactivity: Human SMC1 phosphoSerine 957.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name SMC1A / SMC1
Background Involved in chromosome cohesion during cell cycle and in DNA repair and is a centralcomponent of cohesin complex. The cohesin complex is required for the cohesion ofsister chromatids after DNA replication. The cohesin complex apparently forms a largeproteinaceous ring within which sister chromatids can be trapped. At anaphase, thecomplex is cleaved and dissociates from chromatin, allowing sister chromatids tosegregate. The cohesin complex may also play a role in spindle pole assembly duringmitosis. SMC1 is involved in DNA repair via its interaction with BRCA1 and its relatedphosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branchof S-phase checkpoint. Alternate Names: anti-SMC1L1-structural maintenance of chromosomes-1 like 1 antibody, anti-SMC-1antibody, anti-SMC 1 antibody.
Gene ID 8243
NCBI Accession NP_0062972
Application Notes Suggested working dilutions: immunoprecipitation 2-6 ug/ml,Western Blot 1:200-1:2,000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Lukas, Falck, Bartkova et al.: "Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage." in: Nature cell biology, Vol. 5, Issue 3, pp. 255-60, 2003 (PubMed).

Mochan, Venere, DiTullio et al.: "53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage." in: Cancer research, Vol. 63, Issue 24, pp. 8586-91, 2003 (PubMed).

Wang, Wiltshire, Wang et al.: "ATM-dependent CHK2 activation induced by anticancer agent, irofulven." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39584-92, 2004 (PubMed).

Kurz, Douglas, Lees-Miller: "Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species." in: The Journal of biological chemistry, Vol. 279, Issue 51, pp. 53272-81, 2004 (PubMed).

Goodarzi, Jonnalagadda, Douglas et al.: "Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A." in: The EMBO journal, Vol. 23, Issue 22, pp. 4451-61, 2004 (PubMed).

Ismail, Nystroem, Nygren et al.: "Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4649-55, 2005 (PubMed).

Musio, Montagna, Mariani et al.: "SMC1 involvement in fragile site expression." in: Human molecular genetics, Vol. 14, Issue 4, pp. 525-33, 2005 (PubMed).

Bekker-Jensen, Lukas, Kitagawa et al.: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, 2006 (PubMed).

Biton, Dar, Mittelman et al.: "Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells." in: The Journal of biological chemistry, Vol. 281, Issue 25, pp. 17482-91, 2006 (PubMed).

Pereg, Lam, Teunisse et al.: "Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage." in: Molecular and cellular biology, Vol. 26, Issue 18, pp. 6819-31, 2006 (PubMed).

Biton, Gropp, Itsykson et al.: "ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells." in: DNA repair, Vol. 6, Issue 1, pp. 128-34, 2007 (PubMed).

Pennarun, Granotier, Hoffschir et al.: "Role of ATM in the telomere response to the G-quadruplex ligand 360A." in: Nucleic acids research, Vol. 36, Issue 5, pp. 1741-54, 2008 (PubMed).

Alternatives for antigen "Structural Maintenance of Chromosomes 1A (SMC1A)", type "Antibodies"
Hosts (117), (25), (1), (1)
Reactivities (138), (81), (32), (26), (25), (25), (25), (12), (2), (2), (1)
Applications (106), (42), (40), (33), (30), (15), (14), (8), (7), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Epitopes (44), (13), (12), (6), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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