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SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966)

Details for Product anti-SMC1A Antibody No. ABIN151528, Supplier: Log in to see
Antigen
  • 5830426I24Rik
  • CDLS2
  • DXS423E
  • im:7158706
  • mKIAA0178
  • NV15570
  • SB1.8
  • Sb1.8
  • SMC-1A
  • Smc1
  • SMC1
  • smc1
  • smc1a
  • smc1aa
  • Smc1alpha
  • SMC1alpha
  • Smc1l1
  • SMC1L1
  • smc1l1
  • SMC1L2
  • Smcb
  • SMCB
  • xSMC1
  • zgc:76902
Epitope
pSer966
49
37
15
15
15
13
7
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
216
100
41
4
2
2
2
2
1
1
1
Host
Rabbit
170
43
3
1
1
Clonality
Polyclonal
Conjugate
This SMC1A antibody is un-conjugated
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Proximity Ligation Assay (PLA), Western Blotting (WB)
172
80
59
38
30
29
25
25
25
4
1
1
1
1
Supplier
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 1 (GeneID 8243) around serine 966 according to the numbering given in entry NP_006297.2.
Isotype IgG
Cross-Reactivity (Details) Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, White-tufted-ear marmoset, Crab-eating macaque, Small-eared galago,Northern white-cheeked gibbon.
Purification Immunogen affinity purified
Alternative Name SMC1 (SMC1A Antibody Abstract)
Background Gene Symbol: SMC1A
Gene ID 8243
UniProt Q14683
Research Area DNA/RNA, Cell Cycle, Chromatin and Nuclear Signaling
Application Notes Western Blot 1:500-1:5000, ELISA 1:100-1:2000, Immunohistochemistry 1:500 - 1:2000, Immunocytochemistry/Immunofluorescence 1:250 - 1:5000, Immunoprecipitation 2 - 6 μg/mg of lysate, Immunohistochemistry-Paraffin 1:500 - 1:2000, Proximity Ligation Assay 1:1,000-1:20000
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Tris-buffered Saline and 0.1 % BSA
Buffer contains: 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 4°C. Do not freeze.
Supplier Images
Western Blotting (WB) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Western blot analysis if human Phospho SMC1 (Ser966), using ABIN151528. Sample: Whole...
Western Blotting (WB) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Western Blot: SMC1 [p Ser966] Antibody [ABIN151528] - Whole cell lysate (50 ug) from ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Immunohistochemistry-Paraffin: SMC1 [p Ser966] Antibody [ABIN151528] - Section of hum...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Proximity Ligation Assay (PLA) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Proximity Ligation Assay: SMC1 [p Ser966] Antibody [ABIN151528] - Secondary-conjugate...
Immunofluorescence (IF) image for anti-SMC1A antibody (Structural Maintenance of Chromosomes 1A) (pSer966) (ABIN151528) Immunocytochemistry/Immunofluorescence: SMC1 [p Ser966] Antibody [ABIN151528] - Neoca...
Product cited in: Batenburg, Thompson, Hendrickson, Zhu: "Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation." in: The EMBO journal, Vol. 34, Issue 10, pp. 1399-416, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Lee, Martin, Nakamura, Azghadi, Amiri, Ben-David, Perlman, Gatti, Hu, Lowry: "SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs." in: Nature communications, Vol. 4, pp. 1824, 2013 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Du, Kayali, Bertoni, Fike, Hu, Iversen, Gatti: "Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum." in: Human molecular genetics, Vol. 20, Issue 16, pp. 3151-60, 2011 (PubMed).

Takahashi, Mori, Ohnishi: "The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment." in: Journal of radiation research, Vol. 51, Issue 1, pp. 91-5, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Hu, Du, Nagabayashi, Seeger, Gatti: "ATM is down-regulated by N-Myc-regulated microRNA-421." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 4, pp. 1506-11, 2010 (PubMed). (Sample species: Human). Further details: Western Blotting,ELISA

Nahas, Butch, Du, Gatti: "Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes." in: Clinical chemistry, Vol. 55, Issue 3, pp. 463-72, 2009 (PubMed).

Leung-Pineda, Ryan, Piwnica-Worms: "Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit." in: Molecular and cellular biology, Vol. 26, Issue 20, pp. 7529-38, 2006 (PubMed).