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Details for Product No. ABIN151528

Structural Maintenance of Chromosomes 1A (SMC1A) (pSer966) antibody

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Antigen
Synonyms CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, SMC-1A, 5830426I24Rik, Sb1.8, Smc1, Smc1alpha, Smc1l1, Smcb, mKIAA0178, smc1, smc1a, smc1l1, xSMC1, zgc:76902, im:7158706, SMC1L2, NV15570
Epitope
»Alternatives pSer966
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Proximity Ligation Assay (PLA), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151528
Quantity 0.1 mL
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, whichrepresented a portion of human Structural Maintenance of Chromosomes 1 (GeneID8243) around serine 966 according to the numbering given in entry NP_006297.2.
Specificity Reacts with SMC1 phosphoSerine 966Phosphorylated:Ser966. Species Reactivity: Cross reacts with Human. Localization: Nuclear.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name SMC1A / SMC1
Background Structural maintenance of chromosomes (SMC) proteins are part of the cohesin andcondensin multisubunit complexes that play a critical role in chromosome organization,segregation, gene regulation, and DNA repair. The core cohesin complex includes aheterodimer of SMC1 and SMC3 that functions by forming a ring-like structure that holdssister chromatids together. Cohesin is important to sister chromatid separation andsegregation during mitosis and meiosis and also plays a role in double-strand breakrepair by homologous recombination. Alternate Names: anti-SMC1L1-structural maintenance of chromosomes-1 like 1 antibody, anti-SMC-1antibody, anti-SMC 1 antibody.
Gene ID 8243
NCBI Accession NP_0062972
Application Notes immunoprecipitation 2-6 ug/mg lysate,Western Blot 1:500-1:5000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-buffered Saline containing 0.1% BSA. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Leung-Pineda, Ryan, Piwnica-Worms: "Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit." in: Molecular and cellular biology, Vol. 26, Issue 20, pp. 7529-38, 2006 (PubMed).

Nahas, Butch, Du et al.: "Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes." in: Clinical chemistry, Vol. 55, Issue 3, pp. 463-72, 2009 (PubMed).

Alternatives for antigen "Structural Maintenance of Chromosomes 1A (SMC1A)", type "Antibodies"
Hosts (117), (26), (1), (1)
Reactivities (139), (81), (32), (26), (25), (25), (25), (12), (2), (2), (1)
Applications (107), (42), (41), (33), (30), (15), (14), (8), (8), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Epitopes (45), (12), (12), (7), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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