ATM antibody (Ataxia Telangiectasia Mutated)

Details for Product anti-ATM Antibody No. ABIN151622, Supplier: Log in to see
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated homolog (human)
  • tefu
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • AaeL_AAEL014900
  • MGYG_07634
  • PGTG_14279
  • Atm
  • LOC100349299
Alternatives
anti-Hamster ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
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1
Host
Mouse
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9
3
Clonality (Clone)
Monoclonal ()
Conjugate
This ATM antibody is un-conjugated
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5
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3
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3
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2
2
2
2
2
2
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2
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2
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2
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
219
125
110
88
85
71
58
45
27
21
13
6
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4
2
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Clone 5C2
Isotype IgG1
Purification Protein G purified
Alternative Name ATM (ATM Antibody Abstract)
Background Gene Symbol: ATM
Molecular Weight Theoretical MW: 370 kDa
Gene ID 472
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Application Notes Western Blot 1:500-1:3000, Immunohistochemistry 1:10 - 1:500, Immunocytochemistry/Immunofluorescence 1:100-1:1000, Immunoprecipitation 1:10 - 1:500IHC usage reported in scientific literature (PMID: 21095582). WB: Predicated molecular weight: 350 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 2.43 mg/mL
Buffer PBS
Buffer contains: No Preservative
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -80 °C,-20 °C
Storage Comment Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Ataxia Telangiectasia Mutated (ATM) antibody (ABIN151622) Detection of human ATM protein using ATM 5C2 monoclonal antibody (ABIN151622) in Raji...
Western Blotting (WB) image for anti-Ataxia Telangiectasia Mutated (ATM) antibody (ABIN151622) Western Blot: ATM Antibody (5C2) [ABIN151622] - HeLa whole cell extracts and nuclear ...
Immunofluorescence (IF) image for anti-Ataxia Telangiectasia Mutated (ATM) antibody (ABIN151622) Immunocytochemistry/Immunofluorescence: ATM Antibody (5C2) [ABIN151622] - HeLa cells ...
Product cited in: Barnard, Regan, Hansen, Maycotte, Thorburn, Gustafson: "Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease." in: The Journal of pharmacology and experimental therapeutics, Vol. 358, Issue 2, pp. 282-93, 2016 (PubMed). Method employed by authors: Flow Cytometry (FACS)

Aumailley, Garand, Dubois, Johnson, Marette, Lebel: "Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice." in: PLoS ONE, Vol. 10, Issue 10, pp. e0140292, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunocytochemistry,Immunofluorescence

Milan, Perini, Resnati, Orfanelli, Oliva, Raimondi, Cascio, Bachi, Marcatti, Ciceri, Cenci: "A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells." in: Autophagy, Vol. 11, Issue 7, pp. 1161-78, 2015 (PubMed).

Hou, Toh, Wang: "NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity." in: Cell biochemistry and function, Vol. 30, Issue 3, pp. 233-42, 2012 (PubMed).

Mendez, Cilli, Berardinelli, Viganotti, Ascenzi, Tanzarella, Antoccia, di Masi: "Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation." in: IUBMB life, Vol. 64, Issue 10, pp. 853-61, 2012 (PubMed).

Rankin, Sarkar, Faller: "Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells." in: Journal of cellular physiology, Vol. 227, Issue 6, pp. 2586-94, 2012 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Daniel, Pellegrini, Lee, Guo, Filsuf, Belkina, You, Paull, Sleckman, Feigenbaum, Nussenzweig: "Loss of ATM kinase activity leads to embryonic lethality in mice." in: The Journal of cell biology, Vol. 198, Issue 3, pp. 295-304, 2012 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Gapud, Dorsett, Yin, Callen, Bredemeyer, Mahowald, Omi, Walker, Bednarski, McKinnon, Bassing, Nussenzweig, Sleckman: "Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 2022-7, 2011 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Vogel, Seyffert, Strasser, de Oliveira, Dresch, Glauser, Jolinon, Salvetti, Weitzman, Ackermann, Fraefel: "Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection." in: Journal of virology, Vol. 86, Issue 1, pp. 143-55, 2011 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Alimonti, Nardella, Chen, Clohessy, Carracedo, Trotman, Cheng, Varmeh, Kozma, Thomas, Rosivatz, Woscholski, Cognetti, Scher, Pandolfi: "A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis." in: The Journal of clinical investigation, Vol. 120, Issue 3, pp. 681-93, 2010 (PubMed).

Craig, Holcakova, Finlan, Nekulova, Hrstka, Gueven, DiRenzo, Smith, Hupp, Vojtesek: "DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation." in: Molecular cancer, Vol. 9, pp. 195, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Cam, Easton, High, Houghton: "mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α." in: Molecular cell, Vol. 40, Issue 4, pp. 509-20, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Efeyan, Murga, Martinez-Pastor, Ortega-Molina, Soria, Collado, Fernandez-Capetillo, Serrano: "Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression." in: PLoS ONE, Vol. 4, Issue 5, pp. e5475, 2009 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Gonzalez-Suarez, Redwood, Perkins, Vermolen, Lichtensztejin, Grotsky, Morgado-Palacin, Gapud, Sleckman, Sullivan, Sage, Stewart, Mai, Gonzalo: "Novel roles for A-type lamins in telomere biology and the DNA damage response pathway." in: The EMBO journal, Vol. 28, Issue 16, pp. 2414-27, 2009 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Siehler, Schrauder, Gerischer, Cantor, Marra, Wiesmüller: "Human MutL-complexes monitor homologous recombination independently of mismatch repair." in: DNA repair, Vol. 8, Issue 2, pp. 242-52, 2009 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Ariumi, Kuroki, Dansako, Abe, Ikeda, Wakita, Kato: "The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication." in: Journal of virology, Vol. 82, Issue 19, pp. 9639-46, 2008 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Fernandes, Sun, Price: "Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells." in: The Journal of biological chemistry, Vol. 282, Issue 22, pp. 16577-84, 2007 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Sun, Xu, Roy, Price: "DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity." in: Molecular and cellular biology, Vol. 27, Issue 24, pp. 8502-9, 2007 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Shiotani, Kobayashi, Watanabe, Yamamoto, Sugimura, Wakabayashi: "Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1." in: Molecular cancer research : MCR, Vol. 4, Issue 2, pp. 125-33, 2006 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Jiang, Sun, Chen, Roy, Price: "The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM." in: The Journal of biological chemistry, Vol. 281, Issue 23, pp. 15741-6, 2006 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

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