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BRCA1 antibody (Breast Cancer 1) (Ser1457)

Details for Product anti-BRCA1 Antibody No. ABIN151685, Supplier: Log in to see
Antigen
  • BRCAI
  • BRCC1
  • BROVCA1
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RNF53
Alternatives
anti-Human BRCA1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
Ser1457
33
30
26
24
24
21
20
15
15
15
15
14
13
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10
7
6
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5
5
5
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3
3
3
2
2
2
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2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
428
43
33
4
1
Host
Rabbit
364
69
4
3
Clonality
Polyclonal
Conjugate
This BRCA1 antibody is un-conjugated
18
15
14
9
6
6
6
6
6
6
6
6
3
3
3
2
2
2
Application
Western Blotting (WB)
258
111
103
77
72
65
61
9
8
7
3
3
2
1
1
Supplier
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1457 according to the numbering given in entry NP_009225.1.
Purification affinity purified
Alternative Name BRCA1 / RNF53 (BRCA1 Antibody Abstract)
Background BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumorsuppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylationduring late G1 and S phases of the cell cycle and is transiently dephosphorylated earlyafter M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cellcycle progression. The amount of BRCA protein is highest during S phase and remainselevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1function confers an increased susceptibility for both breast and ovarian cancer. Alternate Names: anti-Breast Cancer 1 antibody, anti-Breast cancer 1 early onset antibody, anti-Breastcancer type 1 susceptibility protein antibody, anti-Breast Ovarian Cancer Susceptibilityantibody, anti-Papillary serous carcinoma of the peritoneum antibody, anti-PSCPantibody, anti-RNF53 antibody.
Gene Symbol: BRCA1
Gene ID 672
NCBI Accession NP_009225
Pathways Cell Division Cycle, DNA Damage Repair
Application Notes Suggested working dilutions: * Western Blot 1:1,000-1:10,000 Immunocytochemistry ND Immunohistochemistry ND *The investigator should determine the optimal dilution for a specific application. This antibody can be used for Western Blot.
Recommended dilutions: Western Blot 1:1000-1:10000
Restrictions For Research Use only
Buffer Tris-citrate/Phosphate buffer, pH 7 to 8, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
Supplier Images
Western Blotting (WB) image for anti-BRCA1 antibody (Breast Cancer 1) (Ser1457) (ABIN151685) anti-Breast Cancer 1 (BRCA1) (Ser1457) antibody
Product cited in: Bekker-Jensen, Lukas, Kitagawa et al.: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, 2006 (PubMed).