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BRCA1 antibody (Breast Cancer 1) (pSer1457)

Details for Product anti-BRCA1 Antibody No. ABIN151685, Supplier: Log in to see
Antigen
  • BRCAI
  • BRCC1
  • BROVCA1
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RNF53
  • breast cancer 1
  • breast cancer 1, early onset
  • Brca1
  • BRCA1
Alternatives
anti-Human BRCA1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer1457
78
34
30
27
24
23
18
18
18
17
15
14
10
10
8
8
6
5
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
549
55
45
10
1
1
Host
Rabbit
376
179
4
3
Clonality
Polyclonal
Conjugate
This BRCA1 antibody is un-conjugated
23
19
19
11
11
8
8
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6
6
6
6
6
5
5
5
5
5
5
5
5
3
2
2
2
Application
Immunoprecipitation (IP), Western Blotting (WB)
328
152
117
109
98
96
95
81
78
6
5
5
5
4
2
2
1
1
Options
Supplier
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1457 according to the numbering given in entry NP_009225.1.
Purification Immunogen affinity purified
Alternative Name BRCA1 (BRCA1 Antibody Abstract)
Background Gene Symbol: BRCA1
Gene ID 672
Research Area DNA/RNA, Proteolysis / Ubiquitin, Transcription Factors, Cancer
Pathways Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway
Application Notes Western Blot 1:1000-1:10000, Immunoprecipitation 2.5 μg/mg of lysateSuggested working dilutions: * Western Blot 1:1,000-1:10,000 Immunocytochemistry ND Immunohistochemistry ND *The investigator should determine the optimal dilution for a specific application. This antibody can be used for Western Blot.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer Tris-Citrate/Phosphate ( pH 7.0 - 8.0)
Buffer contains: 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 4°C. Do not freeze.
Supplier Images
Western Blotting (WB) image for anti-BRCA1 antibody (Breast Cancer 1) (pSer1457) (ABIN151685) anti-Breast Cancer 1 (BRCA1) (pSer1457) antibody
Western Blotting (WB) image for anti-BRCA1 antibody (Breast Cancer 1) (pSer1457) (ABIN151685) Western Blot: BRCA1 [p Ser1457] Antibody [ABIN151685] - Whole Cell Lysate (25ug/lane)...
Product cited in: Rusin, Zajkowicz, Butkiewicz: "Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1." in: Mechanisms of ageing and development, Vol. 130, Issue 8, pp. 528-37, 2009 (PubMed). (Sample species: Human). Further details: Western Blotting

Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, 2006 (PubMed).