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Details for Product No. ABIN151685

Breast Cancer 1 (BRCA1) (pSer1457) antibody

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Antigen
Synonyms BRCA1
Epitope
»Alternatives pSer1457
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151685
Quantity 0.1 mg
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Immunogen Immunogen for this antibody was a phosphorylated synthetic peptide, whichrepresented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine1457 according to the numbering given in entry NP_009225.1.
Specificity ABIN151685 reacts with BRCA1Phosphorylated:Ser1457. Species Reactivity: Human.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name BRCA1 / RNF53
Background BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumorsuppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylationduring late G1 and S phases of the cell cycle and is transiently dephosphorylated earlyafter M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cellcycle progression. The amount of BRCA protein is highest during S phase and remainselevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1function confers an increased susceptibility for both breast and ovarian cancer. Alternate Names: anti-Breast Cancer 1 antibody, anti-Breast cancer 1 early onset antibody, anti-Breastcancer type 1 susceptibility protein antibody, anti-Breast Ovarian Cancer Susceptibilityantibody, anti-Papillary serous carcinoma of the peritoneum antibody, anti-PSCPantibody, anti-RNF53 antibody.
Gene ID 672
NCBI Accession NP_0092251
Application Notes Suggested working dilutions: immunoprecipitation 2.5 ug/mg lysate,Western Blot 1:1,000 to 1:10,000
Restrictions For Research Use only
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Bekker-Jensen, Lukas, Kitagawa et al.: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, 2006 (PubMed).

Alternatives for antigen "Breast Cancer 1 (BRCA1)", type "Antibodies"
Hosts (294), (81), (4), (1)
Reactivities (357), (35), (24), (13), (2), (2), (1), (1), (1), (1)
Applications (217), (95), (90), (84), (73), (70), (63), (4), (2), (2), (1), (1), (1)
Conjugates (16), (16), (10), (9), (9), (9), (9), (9), (9), (9), (9), (6), (3), (3), (1)
Epitopes (37), (33), (24), (17), (16), (15), (15), (14), (13), (12), (11), (7), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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