DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody

Details for Product No. ABIN151732
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Antigen
Synonyms
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, mta, cb983, dmnt1, cb1075, fb05h01, wu:fb05h01, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSF ... show more
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, mta, cb983, dmnt1, cb1075, fb05h01, wu:fb05h01, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSFERASE 1, MET2, METHYLTRANSFERASE 2, METHYLTRANSFERASE I, METI, methyltransferase 1, Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, m.MmuI show less
Reactivity
Human
(153), (64), (59), (52), (42), (33), (24), (6), (2), (1), (1), (1)
Host
Rabbit
(129), (17), (9), (8), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(99), (51), (50), (39), (23), (14), (10), (10), (9), (7), (4), (3), (1), (1)
Pubmed 9 references available
Catalog no. ABIN151732
Quantity 0.1 mL
Price
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Immunogen This antibody was raised against the first 10 kDa of the N-terminus of the DNMT1protein.
Specificity This antibody is specific for DNMT1. Species Reactivity: ABIN151732 recognizes human. Other species have not been tested.
Cross-Reactivity Human
Purification Serum
Alternative Name DNMT1
Background Inactivation of tumor suppressor genes is a key component of the development of allcommon forms of human cancers. Aberrant methylation may contribute to many of thechanges, both physiological and pathological, associated with aging, including tumordevelopment. Hypermethylation of CpG island-containing promoters is associated withthe inactivation of genes important to tumor angiogenesis and progression. DNAmethytransferase (DNMT1) is necessary for the maintenance of the methylationprocess. Alternate Names: anti-DNMT-1 antibody, anti-DNMT 1 antibody, anti-DNMT antibody, anti-DNA9cytosine-5-)-methylatransferase 1 antibody, anti-MCMT antibody, anti-DNA MTaseMmu1 antibody, anti-DNA methyltransferase M.HsaI antibody.
Gene ID 1786
Research Area DNA/RNA
Application Notes Suggested working dilutions: immunoprecipitation 1:1000,Western Blot 1:5000. Positive Controls: T24 cell lysates.
Restrictions For Research Use only
Format Liquid
Buffer Preservative: No preservative.
Storage 4 °C
Supplier Images
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody Western blot analysis using ABIN151732 to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2: 50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.
General Rhee, Bachman, Park et al.: "DNMT1 and DNMT3b cooperate to silence genes in human cancer cells." in: Nature, Vol. 416, Issue 6880, pp. 552-6, 2002 (PubMed).

Suzuki, Gabrielson, Chen et al.: "A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer." in: Nature genetics, Vol. 31, Issue 2, pp. 141-9, 2002 (PubMed).

Beaulieu, Morin, Chute et al.: "An essential role for DNA methyltransferase DNMT3B in cancer cell survival." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28176-81, 2002 (PubMed).

Neumeister, Albanese, Balent et al.: "Senescence and epigenetic dysregulation in cancer." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 11, pp. 1475-90, 2002 (PubMed).

Robert, Morin, Beaulieu et al.: "DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells." in: Nature genetics, Vol. 33, Issue 1, pp. 61-5, 2003 (PubMed).

Bachman, Park, Rhee et al.: "Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene." in: Cancer cell, Vol. 3, Issue 1, pp. 89-95, 2003 (PubMed).

Yang, Seto: "Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression." in: Current opinion in genetics & development, Vol. 13, Issue 2, pp. 143-53, 2003 (PubMed).

Estueve, Chin, Smallwood et al.: "Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication." in: Genes & development, Vol. 20, Issue 22, pp. 3089-103, 2006 (PubMed).

Morey Kinney, Smiraglia, James et al.: "Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model." in: Molecular cancer research : MCR, Vol. 6, Issue 8, pp. 1365-74, 2008 (PubMed).

Hosts (129), (17), (9), (8), (2)
Reactivities (153), (64), (59), (52), (42), (33), (24), (6), (2), (1), (1), (1)
Applications (99), (51), (50), (39), (23), (14), (10), (10), (9), (7), (4), (3), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (16), (13), (12), (12), (8), (6), (6), (5), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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