DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) antibody

Details for Product No. ABIN151733
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Antigen
Synonyms DNMT3A2, M.HsaIIIA, DNMT3A
Reactivity
Human
(71), (31), (23), (13), (1), (1)
Host
Rabbit
(62), (10), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(64), (20), (20), (12), (10), (7), (5), (4), (1)
Pubmed 5 references available
Catalog no. ABIN151733
Quantity 0.1 mL
Price
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Immunogen This antibody was raised against amino acids 10-118 ofthe human DNMT3a protein.
Specificity This antibody is specific for the DNMT3a protein. Species Reactivity: ABIN151733 recognizes human. Other species have notbeen tested. Localization: Nuclear.
Cross-Reactivity Human
Purification Serum
Alternative Name DNMT3A
Background Inactivation of tumor suppressor genes is a key component of the development of allcommon forms of human cancers. Aberrant methylation may contribute to many of thechanges, both physiological and pathological, associated with aging, including tumordevelopment. Hypermethylation of CpG island-containing promoters is associated withthe inactivation of genes important to tumor angiogenesis and progression. DNAmethytransferase (DNMT3a) is necessary for the maintenance of the methylationprocess. Alternate Names: anti-DNMT3A2 antibody, anti-M.HsaIIIA antibody.
Gene ID 1788
UniProt Q9Y6K1
Application Notes Suggested working dilutions: immunoprecipitation 1:1,000,Western Blot 1:1,000. Positive Controls: HCT116 cell lysates
Restrictions For Research Use only
Format Liquid
Buffer 0.1 ml of rabbit antisera. This sera does not contain sodium azide or any otherpreservative.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) antibody Western blot analysis using ABIN151733 to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A.
General Beaulieu, Morin, Chute et al.: "An essential role for DNA methyltransferase DNMT3B in cancer cell survival." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28176-81, 2002 (PubMed).

Weisenberger, Velicescu, Preciado-Lopez et al.: "Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells." in: Gene, Vol. 298, Issue 1, pp. 91-9, 2002 (PubMed).

Robert, Morin, Beaulieu et al.: "DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells." in: Nature genetics, Vol. 33, Issue 1, pp. 61-5, 2003 (PubMed).

Reynolds, Sigaroudinia, Zardo et al.: "Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24790-802, 2006 (PubMed).

Shikauchi, Saiura, Kubo et al.: "SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma." in: Molecular and cellular biology, Vol. 29, Issue 7, pp. 1944-58, 2009 (PubMed).

Hosts (62), (10), (2), (2)
Reactivities (71), (31), (23), (13), (1), (1)
Applications (64), (20), (20), (12), (10), (7), (5), (4), (1)
Conjugates (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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