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Details for Product No. ABIN151745

Nibrin (NBN) antibody

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Antigen
Synonyms AT-V1, AT-V2, ATV, NBS, NBS1, P95, Nbs1, NBN
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151745
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide, which represented a portion of human Nijimegen breakagesyndrome 1 between amino acid residues 625 and 675 encoded in part by exons 12 and13 (LocusLink ID 4683).
Specificity This antibody is specific for human NBS1. Species Reactivity: ABIN151745 recognizes human NBS1. Other species have not been tested. Reactivitywith mouse and rat is unlikely owing to divergence from sequence of the peptide usedfor immunization. Localization: Nuclear.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name Nibrin
Background The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50double-strand break complex. This protein complex has been implicated in Nijmegenbreakage syndrome, an autosomal recessive disorder marked by increased cancerincidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealinga direct molecular link between double-strand break repair and cell cycle checkpointfunctions. Alternate Names: anti-AT V1 antibody, anti-AT V2 antibody,anti- ATV antibody, anti-Cell cycle regulatoryprotein p95 antibody, anti-FLJ10155 antibody, anti-MGC87362 antibody,anti- NBNantibody, anti-NBS 1 antibody, anti-NBS antibody, anti-NBS1 antibody, anti-Nibrinantibody, anti-Nijmegen breakage syndrome antibody, anti-Nijmegen breakagesyndrome protein 1 antibody,anti- p95 antibody.
Gene ID 4683
Application Notes Suggested working dilutions: immunoprecipitation 1 to 4 ul,Western Blot 1:1,000 to 1:10,000
Restrictions For Research Use only
Concentration 1.0 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Heffernan, Unsal-Kaucmaz, Heinloth et al.: "Cdc7-Dbf4 and the human S checkpoint response to UVC." in: The Journal of biological chemistry, Vol. 282, Issue 13, pp. 9458-68, 2007 (PubMed).

Alternatives for antigen "Nibrin (NBN)", type "Antibodies"
Hosts (174), (44)
Reactivities (214), (74), (50), (24), (24), (24)
Applications (177), (71), (56), (40), (31), (29), (19), (18), (5), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2)
Epitopes (46), (18), (16), (8), (7), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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