Nibrin (NBN) antibody

Details for Product No. ABIN151745
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Antigen
Synonyms AT-V1, AT-V2, ATV, NBS, NBS1, P95, Nbs1, NBN
Reactivity
Human
(206), (78), (54), (24), (24), (24)
Host
Rabbit
(167), (42)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(168), (70), (43), (39), (31), (24), (20), (17), (6), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN151745
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide, which represented a portion of human Nijimegen breakagesyndrome 1 between amino acid residues 625 and 675 encoded in part by exons 12 and13 (LocusLink ID 4683).
Specificity This antibody is specific for human NBS1. Species Reactivity: ABIN151745 recognizes human NBS1. Other species have not been tested. Reactivitywith mouse and rat is unlikely owing to divergence from sequence of the peptide usedfor immunization. Localization: Nuclear.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name Nibrin
Background The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50double-strand break complex. This protein complex has been implicated in Nijmegenbreakage syndrome, an autosomal recessive disorder marked by increased cancerincidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealinga direct molecular link between double-strand break repair and cell cycle checkpointfunctions. Alternate Names: anti-AT V1 antibody, anti-AT V2 antibody,anti- ATV antibody, anti-Cell cycle regulatoryprotein p95 antibody, anti-FLJ10155 antibody, anti-MGC87362 antibody,anti- NBNantibody, anti-NBS 1 antibody, anti-NBS antibody, anti-NBS1 antibody, anti-Nibrinantibody, anti-Nijmegen breakage syndrome antibody, anti-Nijmegen breakagesyndrome protein 1 antibody,anti- p95 antibody.
Gene ID 4683
Application Notes Suggested working dilutions: immunoprecipitation 1 to 4 ul,Western Blot 1:1,000 to 1:10,000
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.1% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Nibrin (NBN) antibody Detection of Human NBS1 by Immunoprecipitation and Western Blot. Sample: Nuclear extract (50 mcg for WB, 1 mg for IP) from HeLa cells. Antibody: Affinity purified rabbit anti-NBS1 (ABIN151745) used at 0.08 mcg/ml for WB and 1.25 mcg/mg lysate for IP. Detection: Chemiluminescence. (* band is believed to be a proteolytic fragment of NBS1).
General Heffernan, Unsal-Kaucmaz, Heinloth et al.: "Cdc7-Dbf4 and the human S checkpoint response to UVC." in: The Journal of biological chemistry, Vol. 282, Issue 13, pp. 9458-68, 2007 (PubMed).

Hosts (167), (42)
Reactivities (206), (78), (54), (24), (24), (24)
Applications (168), (70), (43), (39), (31), (24), (20), (17), (6), (2), (2), (1)
Conjugates (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (48), (17), (8), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

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Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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