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Aurora A antibody (Aurora Kinase A) (C-Term)

Details for Product anti-AURKA Antibody No. ABIN151760, Supplier: Login to see New
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87A7-9/2, Aur-A, AurA, CG3068, Dmel\\CG3068, aur-A, aurA, ck10, ck[10], l(3)87Ac, l(3)ck10, Aurora-A, Eg2, aik, ark1, aur-a, aura, aurora2, btak, pEg2, stk15, stk6, stk7, wu:fb37c10, wu:fc02c02, zgc:1 ... show more
87A7-9/2, Aur-A, AurA, CG3068, Dmel\\CG3068, aur-A, aurA, ck10, ck[10], l(3)87Ac, l(3)ck10, Aurora-A, Eg2, aik, ark1, aur-a, aura, aurora2, btak, pEg2, stk15, stk6, stk7, wu:fb37c10, wu:fc02c02, zgc:100912, AURKA, aurka, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, AIRK1, AU019385, AW539821, Ark1, Ayk1, IAK, IAK1, Stk6, ARK-1, aurka-a show less
C-Term, AA 1-19
(46), (44), (32), (15), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(228), (77), (49), (14), (8), (8), (3), (2), (1), (1), (1), (1)
(178), (57), (20)
This Aurora A antibody is un-conjugated
(12), (6), (6), (5), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Microarray (MA)
(193), (88), (77), (55), (40), (32), (19), (16), (12), (5), (4), (2), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mL
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to amino acids 1-19 of human Aurora B with C-terminal added cysteine conjugated to KLH
Specificity Aurora B
Purification affinity purified
Alternative Name Aurora kinase (AURKA Antibody Abstract)
Background Chromosomal segregation during mitosis as well as meiosis is regulated by kinases andphosphatases. The Aurora kinases associate with microtubules during chromosomemovement and segregation. Aurora kinase B localizes to microtubules nearkinetochores, specifically to the specialized microtubules called K-fibers, and Aurorakinase A localizes to centrosomes. Alternate Names: anti-AIK2 antibody, anti-AIM1 antibody, anti-ARK2 antibody, anti-AURKB antibody,anti-Aurora 1 antibody, anti-Aurora kinase B antibody, anti-Aurora- and Ipl1-likemidbody-associated protein 1 antibody, anti-Aurora-related kinase 2 antibody,anti-Aurora/IPL1 related kinase 2 antibody, anti-IPL1 antibody.
Gene Symbol: AURKB
Gene ID 9212, 20877, 114592
Pathways Cell Division Cycle
Application Notes By Western blot, it detects a band of approximately 39 kDa. It can also be used for indirect immunofluorescence and immunoprecipitation. Immunohistochemistry was reported in scientific literature. The IF dilution given is for indirect.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:50, Immunohistochemistry 1:10-1:2000, Immunoprecipitation 60 µg / 300 µg lysate, Microarray, Western Blot 1:1000-1:2000
Restrictions For Research Use only
Format Liquid
Concentration 12.5 mg/mL
Buffer 0.01 M PBS, pH 7.4, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-Aurora A antibody (Aurora Kinase A) (C-Term) (ABIN151760) anti-Aurora Kinase A (AURKA) (AA 1-19), (C-Term) antibody
Product cited in: Lee, Frolov, Li et al.: "Targeting Aurora kinases for the treatment of prostate cancer." in: Cancer research, Vol. 66, Issue 10, pp. 4996-5002, 2006 (PubMed).

Hsu, Sun, Li et al.: "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes." in: Cell, Vol. 102, Issue 3, pp. 279-91, 2000 (PubMed).

Background publications Adams, Eckley, Vagnarelli et al.: "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells." in: Chromosoma, Vol. 110, Issue 2, pp. 65-74, 2001 (PubMed).

Giet, Prigent: "Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases." in: Journal of cell science, Vol. 112 ( Pt 21), pp. 3591-601, 1999 (PubMed).

Catalog No. ABIN151760
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