Stromal Antigen 2 (STAG2) antibody

Details for Product No. ABIN151766
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Antigen
Synonyms STAG2, stag2, SA-2, SA2, SCC3B, bA517O1.1, 9230105L23Rik, B230112I07Rik, SAP2, RGD1562042, XSA2, sa2, sa2-a
Reactivity
Human
(39), (19), (15), (11), (3), (1), (1)
Host
Goat
(17), (12), (11), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
(31), (18), (11), (9), (9), (8), (8), (2)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN151766
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Immunogen A 31 amino acid synthetic peptide, which represented a portion of human Stromal Antigen 2 encoded within exon 31 (LocusLink ID 10735)
Specificity NB100-300 is specific for human SA2 protein.
Purification affinity purified
Alternative Name STAG2 / Stromal gen 2
Background SA2 is a component of the cohesin complex, which is required for the cohesion of sisterchromatids after DNA replication. The cohesin complex apparently forms a largeproteinaceous ring within which, sister chromatids can be trapped. At anaphase, thecomplex is cleaved and dissociates from chromatin, allowing sister chromatids tosegregate. The cohesin complex may also play a role in spindle pole assembly duringmitosis.The subunit interacts directly with RAD21 in cohesin complex. Cohesin complexes arecomposed of a heterodimer between a SMC1 protein (SMC1L1 or SMC1L2) and SMC3,which are attached via their hinge domain, and RAD21 links them at their heads, andone STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 ismutually exclusive with STAG1 and STAG3. Alternate Names: anti-SA-2 antibody, anti-STAG2 antibody, anti-Stromal Antigen 2 antibody, anti-CohesinSubunit SA2 antibody, anti-SCC3 homolog 2 antibody.
Gene Symbol: STAG2
Gene ID 10735
Application Notes NB 100-300 may be used for Western Blot where a band at ~140 kD is seen on SDS-PAGE. It may also be used for immunocytochemistry. Suggested working dilutions: * Western Blot 1:1,000-1:10,000 (ECL) Immunocytochemistry 1:500-1:2,000 Immunoprecipitation Not Done *The investigator should determine the optimal working dilution for a specific application.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:500-1:2000, Western Blot 1:1000-1:10000
Restrictions For Research Use only
Format Liquid
Buffer Tris-citrate/Phosphate buffer, pH 7 to 8, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
Supplier Images
anti-Stromal Antigen 2 (STAG2) antibody anti-Stromal Antigen 2 (STAG2) antibody
General Yalcin, Zhang, Luciano et al.: "Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25692-705, 2008 (PubMed).

Zhang, Kuznetsov, Sharan et al.: "A handcuff model for the cohesin complex." in: The Journal of cell biology, Vol. 183, Issue 6, pp. 1019-31, 2008 (PubMed).

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