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Details for Product No. ABIN151770

Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

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Antigen
Synonyms 53BP1, p202, Trp53bp1, Tp53bp1, m53BP1, TP53BP1, MGC160112
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN151770
Quantity 0.1 mL
Price
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Immunogen The epitope recognized by this antibody maps to a region between residues 350 and400 of human tumor protein p53 binding protein 1 using the numbering given in entryNP_005648.1 (GeneID 7158).
Specificity ABIN151770 is specific for human 53BP1 protein. Species Reactivity: Human and Mouse.
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name TP53BP1
Background P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53 Binding Protein 1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody,anti-Tumor Protein p53 Binding Protein 1 antibody.
Gene ID 7158
NCBI Accession NP_0056481
Research Area Transcription Factors
Application Notes Suggested working dilutions: flow cytometry / FACS analysis 1.5 mcg/ml,Western Blot 1:1000-1:10000 ,Immunocytochemistry 1:100 -1:500. Positive Controls: U205, 293T, MO59K cell lysates (human) and MEF lysates (mouse)
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Riballo, Kuehne, Rief et al.: "A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci." in: Molecular cell, Vol. 16, Issue 5, pp. 715-24, 2004 (PubMed).

Hockemeyer, Palm, Else et al.: "Telomere protection by mammalian Pot1 requires interaction with Tpp1." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 754-61, 2007 (PubMed).

Konishi, de Lange: "Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2." in: Genes & development, Vol. 22, Issue 9, pp. 1221-30, 2008 (PubMed).

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts (115), (10), (1)
Reactivities (123), (79), (42), (36), (12), (12)
Applications (86), (42), (32), (30), (30), (22), (21), (15), (4), (2)
Conjugates (8), (8), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (17), (13), (12), (10), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)
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