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Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

Antigen

Tumor Protein P53 Binding Protein 1 (TP53BP1)
Synonyms p202, 53BP1, FLJ41424, MGC138366, Trp53bp1, TP53BP1, MGC160112
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
3 references available
Catalog no. ABIN151770
Quantity 0.1 ml  (1 mg/ml)  (Variants)
Price Product not available in this region.
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody (2)

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody (3)

Additional Information
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Alternative name TP53BP1
Gene ID 7158
NCBI Acession NP_0056481
Immunogen The epitope recognized by this antibody maps to a region between residues 350 and400 of human tumor protein p53 binding protein 1 using the numbering given in entryNP_005648.1 (GeneID 7158).
Cross-Reactivity Human, Mouse (Murine)
Description P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53 Binding Protein 1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody,anti-Tumor Protein p53 Binding Protein 1 antibody.
Specificity ABIN151770 is specific for human 53BP1 protein. Species Reactivity: Human and Mouse.

Application Details
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Application Notes Suggested working dilutions: flow cytometry / FACS analysis 1.5 mcg/ml,Western Blot 1:1000-1:10000 ,Immunocytochemistry 1:100 -1:500. Positive Controls: U205, 293T, MO59K cell lysates (human) and MEF lysates (mouse)
Concentration 1 mg/ml
Purification Aff - Purified
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.
Storage Store at 4C. Do not freeze.
Research Area Transcription Factors
Restrictions For Research Use only

Publications
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Riballo, Kuehne, Rief et al.: "A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci." in: Molecular cell, Vol. 16, Issue 5, pp. 715-24, 2004 (PubMed).

Hockemeyer, Palm, Else et al.: "Telomere protection by mammalian Pot1 requires interaction with Tpp1." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 754-61, 2007 (PubMed).

Konishi, de Lange: "Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2." in: Genes & development, Vol. 22, Issue 9, pp. 1221-30, 2008 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts Rabbit (63), Mouse (3), Goat (1)
Reactivities Human (67), Mouse (Murine) (48), Rat (Rattus) (29), Dog (Canine) (23), Cow (Bovine) (5), Horse (Equine) (5), Pig (Porcine) (5)
Applications Immunofluorescence (IF) (45), Western Blotting (WB) (28), ELISA (15), Immunocytochemistry (ICC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (6), Immunoprecipitation (IP) (4), Immunoelectron Microscopy (IEM) (2), Flow Cytometry (FACS) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy5.5 (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes Ser1778 (11), pSer1778 (8), pSer29,pSer25 (4), AA 1-337 (2), N-Term (2), pSer25 (2), AA 1614-1972 (1), C-Term (1), Internal Region (1), Ser25, Ser29 (1), pSer6 (1), pThr46,pThr37 (1)