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Details for Product No. ABIN151771

Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

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Synonyms 53BP1, p202, Trp53bp1, Tp53bp1, m53BP1, TP53BP1, MGC160112
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunofluorescence (IF), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN151771
Quantity 0.1 mg
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Immunogen The epitope recognized by this antibody maps to a region between residues 1925 andthe C-terminus (residue 1972) of human tumor protein p53 binding protein 1 using thenumbering given in entry NP_005648.1 (GeneID 7158).
Specificity ABIN151771 is specific for human 53BP1 protein. Species Reactivity: Human and Mouse in Western Blot and immunocytochemistry/immunofluorescence andit reacts with Mouse in immunocytochemistry/immunofluorescence (Western Blot hasnot been done using this antibody on Mouse protein).
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name TP53BP1
Background P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.
Gene ID 7158
NCBI Accession NP_0056481
Research Area Transcription Factors
Application Notes Suggested working dilutions: Western Blot 1:200- 1:10000,Immunocytochemistry 1:200-1:1000. Positive Controls: U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse)
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).

Rothkamm, Balroop, Shekhdar et al.: "Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure." in: Radiology, Vol. 242, Issue 1, pp. 244-51, 2006 (PubMed).

Ibarra, Schwob, Muendez: "Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 26, pp. 8956-61, 2008 (PubMed).

Guirouilh-Barbat, Redon, Pommier: "Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex." in: Molecular biology of the cell, Vol. 19, Issue 9, pp. 3969-81, 2008 (PubMed).

Wirthner, Wrann, Balamurugan et al.: "Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts." in: Carcinogenesis, Vol. 29, Issue 12, pp. 2306-16, 2008 (PubMed).

Palm, Hockemeyer, Kibe et al.: "Functional dissection of human and mouse POT1 proteins." in: Molecular and cellular biology, Vol. 29, Issue 2, pp. 471-82, 2008 (PubMed).

Solier, Sordet, Kohn et al.: "Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 68-82, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts (115), (10), (1)
Reactivities (123), (79), (42), (36), (12), (12)
Applications (86), (42), (32), (30), (30), (22), (21), (16), (4), (2)
Conjugates (8), (8), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (17), (13), (12), (10), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)