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Details for Product No. ABIN151772

Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

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Antigen
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik, ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1
Epitope
»Alternatives pSer1981
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN151772
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide with a phosphorylated serine (1981).
Clone 10H11-E12
Isotype IgG1
Specificity ABIN151772 is specific for the human ATM kinase.Phosphorylated:Ser1981. Species Reactivity: ABIN151772 reacts with human and rat.
Cross-Reactivity Human
Purification Ascites
Alternative Name ATM
Background ATM-kinase plays an important regulatory role. DNA damage caused by such things asionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions thatregulate cell cycle, apoptosis, and DNA damage repair. Alternate Names: anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylatedSer 1981 antibody, anti-ATM (phospho S1981) antibody.
Gene ID 472, 300711
Application Notes Suggested working dilutions: Western Blot 1:1000,Immunocytochemistry 1:1000. Positive Controls: Irradiated normal human fibroblasts. No reactivity against un-irradiated cell extracts.
Restrictions For Research Use only
Format Liquid
Concentration 12.7 mg/ml
Buffer Preservative: 0.05 sodium azide.
Preservative Sodium azide
Storage -20 °C
Bakkenist, Kastan: "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." in: Nature, Vol. 421, Issue 6922, pp. 499-506, 2003 (PubMed).

Yalcin, Zhang, Luciano et al.: "Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25692-705, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts (154), (58), (18), (6), (4)
Reactivities (229), (73), (43), (5), (4), (1), (1)
Applications (142), (68), (53), (48), (42), (40), (34), (12), (10), (7), (3), (2), (2)
Conjugates (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Epitopes (52), (15), (12), (12), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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