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Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Antigen

Ataxia Telangiectasia Mutated (ATM)
Synonyms AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, AI256621, C030026E19Rik, ATM, Tefu, atm/tefu, dATM, tef, DmelCG6535, CG6535, Xatm
Binding Site
Alternatives

pSer1981
Clonality Monoclonal (10H11-E12)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunofluorescence (IF), Western Blotting (WB)
3 references available
Catalog no. ABIN151772
Quantity 0.1 ml  (12.7 mg/ml)  (Variants)
Price Product not available in this region.
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anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Additional Information
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Alternative name ATM
Gene ID 472, 300711
Immunogen A synthetic peptide with a phosphorylated serine (1981).
Cross-Reactivity Human
Format Ascites
Isotype IgG1
Clone 10H11-E12
Description ATM-kinase plays an important regulatory role. DNA damage caused by such things asionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions thatregulate cell cycle, apoptosis, and DNA damage repair. Alternate Names: anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylatedSer 1981 antibody, anti-ATM (phospho S1981) antibody.
Specificity ABIN151772 is specific for the human ATM kinase.Phosphorylated:Ser1981. Species Reactivity: ABIN151772 reacts with human and rat.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:1000,Immunocytochemistry 1:1000. Positive Controls: Irradiated normal human fibroblasts. No reactivity against un-irradiated cell extracts.
Concentration 12.7 mg/ml
Purification Ascites
Buffer Preservative: 0.05 sodium azide.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
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Bakkenist, Kastan: "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." in: Nature, Vol. 421, Issue 6922, pp. 499-506, 2003 (PubMed).

Yalcin, Zhang, Luciano et al.: "Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25692-705, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts Rabbit (90), Mouse (32), Goat (8), Sheep (5), Chicken (2)
Reactivities Human (129), Mouse (Murine) (57), Rat (Rattus) (43), Hamster (2)
Applications Western Blotting (WB) (66), Immunofluorescence (IF) (44), ELISA (28), Immunoprecipitation (IP) (28), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), Immunohistochemistry (IHC) (19), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Fluorescence Microscopy (FM) (5), Immunocytochemistry (ICC) (5), Dot Blot (Dot) (2), Flow Cytometry (FACS) (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), PE (2), PE,Cy5.5 (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pSer1981 (27), pTyr170 (18), AA 1391-1693 (4), AA 2577-3056 (4), AA 1-308 (3), AA 1980-2338 (3), AA 980-1512 (3), Ser1981 (3), pSer1981,AA 1974-1988 (3), C-Term (2), N-Term (2), AA 1248-1332 (1), AA 1653-2032 (1), AA 1750-1800 (1), AA 2050-2717 (1), AA 2550-2600 (1), AA 5055-6585 (1), Internal Region (1)