Ataxia Telangiectasia and Rad3 Related (ATR) antibody

Antigen: Ataxia Telangiectasia and Rad3 Related (ATR)

Synonyms: FRP1, MEC1, SCKL, SCKL1, ATR, atr, XATR, frp1, mec1, sckl, sckl1

Clonality: Monoclonal (2B5)

Host: Mouse

Reactivity: Human

Application: Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)

Catalog no.: ABIN151774

Additional Information

Alternative name: ATR / FRP1

Gene ID: 545

Immunogen: A synthetic recombinant fragment, corresponding to amino acids 710-1100 of humanATR.

Cross-Reactivity: Human

Isotype: IgG

Clone: 2B5

Description: Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member ofthe phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has apredictedmolecular mass of approximately 301 kDa, and it has been shown to be involved incellular responses to DNA damage. Specifically, it plays a role in checkpoint activationin response to either the presence of stalled replication forks, or by the presence oflesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice. Alternate Names: anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATRantibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody,anti-Seckel syndrome antibody.

Specificity: ABIN151774 is specific for the human ATR. Species Reactivity: Human. Other species not yet tested.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:500-1:1000. Positive Controls: Raji cell lysates

Concentration: 1 mg/ml

Purification: Purified

Buffer: PBS

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Restrictions: For Research Use only

Images

Western Blot analysis of ATR, using ABIN151774. Sample: Raji whole cell extracts.

Publications

Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).

Post, Weng, Cimprich et al.: "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 23, pp. 13102-7, 2001 (PubMed).