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Details for Product No. ABIN151774

Ataxia Telangiectasia and Rad3 Related (ATR) antibody

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Antigen
Synonyms
FCTCS, FRP1, MEC1, SCKL, SCKL1, XATR, frp1, mec1, sckl, sckl1, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, ATRAD3, Ataxia telangiectasia-mutated and RAD3-related, MHK7. ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151774
Quantity 0.1 mL
Price
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Immunogen A synthetic recombinant fragment, corresponding to amino acids 710-1100 of humanATR.
Clone 2B5
Isotype IgG
Specificity ABIN151774 is specific for the human ATR. Species Reactivity: Human. Other species not yet tested.
Cross-Reactivity Human
Purification Purified
Alternative Name ATR / FRP1
Background Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member ofthe phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has apredictedmolecular mass of approximately 301 kDa, and it has been shown to be involved incellular responses to DNA damage. Specifically, it plays a role in checkpoint activationin response to either the presence of stalled replication forks, or by the presence oflesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice. Alternate Names: anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATRantibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody,anti-Seckel syndrome antibody.
Gene ID 545
Application Notes Suggested working dilutions: Western Blot 1:500-1:1000. Positive Controls: Raji cell lysates
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS
Storage -20 °C
Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).

Post, Weng, Cimprich et al.: "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 23, pp. 13102-7, 2001 (PubMed).

Alternatives for antigen "Ataxia Telangiectasia and Rad3 Related (ATR)", type "Antibodies"
Hosts (22), (6), (1)
Reactivities (26), (9), (4), (2), (2), (1), (1), (1), (1)
Applications (20), (8), (7), (5), (2), (1)
Epitopes (3), (2), (1), (1), (1), (1), (1), (1)
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