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Details for Product No. ABIN151804

NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) antibody

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Synonyms HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, CG9938, Dmel\\CG9938, Hec1, NDC80, dNdc80, dmNdc80, hec1, kntc2, kntc2l, wu:fb52e02, zgc:111801, ndc10, tid3
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN151804
Quantity 0.1 mL
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Immunogen Recombinant protein encoding amino acids 56-642 of human HEC1 purified from E. coli.
Clone 9G3-23
Isotype IgG2b
Specificity Species Reactivity: ABIN151804 reacts with human. Other species have not been tested.
Cross-Reactivity Human
Purification Purified
Alternative Name NDC80
Background Human HEC1 is a coiled-coil protein that has been demonstrated to have a role inM-phase progression. It is essential for proper chromosome segregation. Its depletionresults in the impairment of chromosome congression and results in spindle checkpointactivation. Alternate Names: anti-HEC antibody, anti-Highly Expressed in Cancer antibody, anti-KinetochoreAssociated 2 antibody, anti-KNTC2 antibody.
Gene ID 10403
Application Notes Suggested working dilutions: immunofluorescence 4-10 ug/ml,immunoprecipitation 1-5 ug,Western Blot 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer PBS [pH7.4]. Preservative: No preservative.
Storage -20 °C
Chen, Riley, Chen et al.: "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6049-56, 1997 (PubMed).

Zheng, Chen, Riley et al.: "Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p." in: Molecular and cellular biology, Vol. 20, Issue 10, pp. 3529-37, 2000 (PubMed).

Martin-Lluesma, Stucke, Nigg: "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2." in: Science (New York, N.Y.), Vol. 297, Issue 5590, pp. 2267-70, 2002 (PubMed).

Ganem, Compton: "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK." in: The Journal of cell biology, Vol. 166, Issue 4, pp. 473-8, 2004 (PubMed).

Ciferri, De Luca, Monzani et al.: "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore." in: The Journal of biological chemistry, Vol. 280, Issue 32, pp. 29088-95, 2005 (PubMed).

Alternatives for antigen "NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80)", type "Antibodies"
Hosts (42), (11), (9)
Reactivities (60), (22), (14), (12), (12), (12)
Applications (48), (23), (12), (12), (10), (6), (6), (4), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (2), (2), (1), (1), (1), (1)