BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (AA 647-1043) antibody

Details for Product No. ABIN151815
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Antigen
Synonyms MGC68622, BRIP1, fancj, si:ch211-158l18.1, BACH1, FANCJ, OF, 3110009N10Rik, 8030460J03Rik, Bach1, FACJ, Fancj
Epitope
AA 647-1043
(14), (12), (9), (8), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(67), (27), (24), (12), (12), (12), (12), (12), (1)
Host
Mouse
(53), (17), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(47), (20), (13), (11), (8), (4), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN151815
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Immunogen Fusion protein corresponding to amino acids 647-1043 of human FANCJ.
Clone GO11-3E6
Isotype IgG1 kappa
Purification Ascites
Alternative Name BRIP1 / FANCJ
Background BRIP1 (also called BACH1) is a helicase that interacts with the BRCT domain of BRCA1and has a role in BRCA1-dependent DNA repair and checkpoint. BRIP1 has recentlybeen found to be defective in Fanconi anemia complementation group J. BRIP1/FANCJhas a function in the Fanconi anemia pathway that is independent of BRCA1 anddownstream of FANCD2 activation. (1-4). Alternate Names: anti-FANCJ protein antibody, anti-BACH 1 antibody, anti-BACH1 BRIP1 antibody,anti-BRIP 1 antibody, anti-BRAC 1 Associated C Terminal Helicase 1 antibody,anti-BRCA 1 Interacting Protein 1 antibody, anti-Fanconi anemia group J protein.
Gene Symbol: BRIP1
Gene ID 83990
UniProt Q9BX63
Application Notes This FANCJ (GO11-3E6) antibody is useful for Western blot, where a band can be seen at ~130 kDa.
Recommended dilutions: Immunoprecipitation, Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Ohira, Seki, Nagase et al.: "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1." in: Genomics, Vol. 47, Issue 2, pp. 300-6, 1998 (PubMed).

Cantor, Bell, Ganesan et al.: "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function." in: Cell, Vol. 105, Issue 1, pp. 149-60, 2001 (PubMed).

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