Solute Carrier Family 31, Member 1 (SLC31A1) antibody

Antigen: Solute Carrier Family 31, Member 1 (SLC31A1)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN151866

Additional Information

Alternative name: CTR1

Gene ID: 1317, 20529, 171135

UniProt: O15431

Immunogen: A synthetic peptide derived from a C-terminal sequence of the human CTR1.

Cross-Reactivity: Human

Description: The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor formany enzymes. Cu-related genetic diseases, such as Menkes disease and Wilsondisease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is ahigh-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family ofprotein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 providesthe primary avenue for copper uptake in mammalian cells, thereby, affecting Cuhomeostasis and embryonic development. Alternate Names: anti-copper transporter 1 antibody, anti-COPT1 antibody, anti-CTR1 antibody,anti-hCTR1 antibody, anti-solute carrier family 31 (copper transporters) member 1antibody, anti-SLC31A1 antibody. Related Diseases: Menkes disease and Wilson disease

Specificity: Species Reactivity: Reacts with human, mouse, rat, Xenopus, Zebrafish, and pig.

Application Details

Application Notes: Suggested working dilutions: Immunohistochemistry-Paraffin 1:250. Positive Controls: Human breast cancer and kidney tissue

Concentration: 1 mg/ml

Purification: Aff - Purified

Buffer: Preservative: 0.1% sodium azide.

Storage: Store at 4C. Do not freeze.

Restrictions: For Research Use only

Images

The photo on the left is antibody staining of hCTR1 overexpressing cell line. The photo on the right is antibody plus peptide competition staining.

Panel 1: human CTR1 staining of breast cancer tissue. Panel 2: human CTR1-antigen competition in breast cancer tissue.

Publications

Holzer, Varki, Le et al.: "Expression of the human copper influx transporter 1 in normal and malignant human tissues." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 54, Issue 9, pp. 1041-9, 2006 (PubMed).

Peng, Lu, Janisse et al.: "PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 47, Issue 10, pp. 1649-52, 2006 (PubMed).

Holzer, Howell: "The internalization and degradation of human copper transporter 1 following cisplatin exposure." in: Cancer research, Vol. 66, Issue 22, pp. 10944-52, 2006 (PubMed).

Jandial, Farshchi-Heydari, Larson et al.: "Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 553-60, 2009 (PubMed).