CAMP Responsive Element Binding Protein 1 (CREB1) (pSer121) antibody

Details for Product No. ABIN151873
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Antigen
Synonyms CREB, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, creb, creb1, zgc:55598, CREB1, Creb1
Epitope
pSer121
(76), (35), (26), (18), (14), (13), (9), (7), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(335), (239), (225), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1)
Host
Rabbit
(297), (54), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(258), (138), (131), (74), (60), (39), (29), (21), (7), (4), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN151873
Quantity 0.1 mL
Price
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Immunogen A phospho-peptide spanning the Ser-121 phosphorylation site of human CREB.
Specificity This antibody is specific for the Ser-121-phosphorylated form of CREB.Phosphorylated:Ser121. Species Reactivity: Reacts with human and mouse CREB. Other species have not been tested. Localization: Nuclear.
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name CREB1
Background Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zippertranscription factor that binds the cyclic AMP response element (CRE) and activatestranscription in response to a variety of extracellular signals including neurotransmitters,hormones, membrane depolarization, and growth and neurotrophic factors. CREB isalso regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 bythe ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation. Alternate Names: anti-Active transcription factor CREB antibody, anti-cAMP responsive element bindingprotein 1 antibody, anti-CREB1 antibody, anti-MGC9284 antibody, anti-Transactivatorprotein antibody.
Gene ID 1385, 12912
Application Notes Suggested working dilutions: immunoprecipitation.5 ug,Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml
Buffer Tris 50% glycerol. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-CAMP Responsive Element Binding Protein 1 (CREB1) (pSer121) antibody Detection of phospho-CREB in human HEK 293T cells. Top panel: probed with ABIN151873. Bottom panel: probed with CREB antibody. Lanes 2 and 4 treated with lambda phosphatase, lanes 3 and 4 treated with 0.2mM H202.
General Shi, Venkataraman, Dodson et al.: "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 16, pp. 5898-903, 2004 (PubMed).

Shi, Dodson, Shaikh et al.: "Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40195-200, 2005 (PubMed).

Dodson, Tibbetts: "DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1692-7, 2006 (PubMed).

Shanware, Trinh, Williams et al.: "Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage." in: The Journal of biological chemistry, Vol. 282, Issue 9, pp. 6283-91, 2007 (PubMed).

Shi, Dodson, Mukhopadhyay et al.: "Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies." in: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9236-43, 2007 (PubMed).

Hosts (297), (54), (1)
Reactivities (335), (239), (225), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1)
Applications (258), (138), (131), (74), (60), (39), (29), (21), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (76), (35), (26), (18), (14), (13), (9), (7), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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