Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody

Details for Product No. ABIN151887
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms FIH1, 2310046M24Rik, A830014H24Rik, cb728, id:ibd5139, HIF-1a, HIF1a, hif-1a, hif1a
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(63), (28), (26), (15), (15), (12), (12), (2), (2)
Host
Rabbit
(48), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(51), (15), (14), (11), (10), (10), (3), (2), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN151887
Quantity 0.1 mL
Price
Contact our Customer Service for availability and price in your country.
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A C-terminal region synthetic peptide made to the human FIH protein sequence(between residues 300 and the C-terminus).
Specificity This antibody is specific for FIH-1 protein. Species Reactivity: Human and rat. Localization: Nuclear.
Cross-Reactivity Human, Rat (Rattus)
Purification Purified
Alternative Name HIF1AN / FIH1
Background Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activityby binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alphatransactivation function by recruiting histone deacetylases. Involvement of VHL inassociation with FIH provides a unifying mechanism for the modulation of HIF-1 alphaprotein stabilization and transcriptional activation in response to changes in cellularoxygen concentration. Alternate Names: anti-FIH antibody, anti-FIH1 antibody, anti-HIF1AN antibody, anti-Hypoxia-induciblefactor 1 alpha inhibitor antibody, anti-Hypoxia-inducible factor asparagine hydroxylaseantibody, anti-prolyl hydroxylase antibody, ant-FIH-1 antibody.
Gene ID 55662, 29560
UniProt Q9NWT6
Application Notes Suggested working dilutions: immunohistochemistry 1:100,Western Blot 1:1,000-1:5,000. Positive Controls: Rat astrocytes and C6 and U251 gliomas
Restrictions For Research Use only
Format Liquid
Concentration 1.25 mg/ml
Buffer Tris-citrate/phosphate [pH 7-8] buffer. Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody Detection of FIH-1 in rat brain tissue, using ABIN151887 (1:100).
anti-Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody (2) Detection of FIH-1 in rat and human samples, using ABIN151887 (1:500).
General Li, Wang, Dutta et al.: "Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7345-53, 2007 (PubMed).

Hosts (48), (14)
Reactivities (63), (28), (26), (15), (15), (12), (12), (2), (2)
Applications (51), (15), (14), (11), (10), (10), (3), (2), (2), (2), (1)
Conjugates (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (10), (3), (3), (2), (2), (2)
back to top