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Details for Product No. ABIN151887

Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody

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Antigen
Synonyms FIH1, 2310046M24Rik, A830014H24Rik, cb728, id:ibd5139, HIF-1a, HIF1a, hif-1a, hif1a
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151887
Quantity 0.1 mL
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Immunogen A C-terminal region synthetic peptide made to the human FIH protein sequence(between residues 300 and the C-terminus).
Specificity This antibody is specific for FIH-1 protein. Species Reactivity: Human and rat. Localization: Nuclear.
Cross-Reactivity Human, Rat (Rattus)
Purification Purified
Alternative Name HIF1AN / FIH1
Background Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activityby binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alphatransactivation function by recruiting histone deacetylases. Involvement of VHL inassociation with FIH provides a unifying mechanism for the modulation of HIF-1 alphaprotein stabilization and transcriptional activation in response to changes in cellularoxygen concentration. Alternate Names: anti-FIH antibody, anti-FIH1 antibody, anti-HIF1AN antibody, anti-Hypoxia-induciblefactor 1 alpha inhibitor antibody, anti-Hypoxia-inducible factor asparagine hydroxylaseantibody, anti-prolyl hydroxylase antibody, ant-FIH-1 antibody.
Gene ID 55662, 29560
UniProt Q9NWT6
Application Notes Suggested working dilutions: immunohistochemistry 1:100,Western Blot 1:1,000-1:5,000. Positive Controls: Rat astrocytes and C6 and U251 gliomas
Restrictions For Research Use only
Format Liquid
Concentration 1.25 mg/ml
Buffer Tris-citrate/phosphate [pH 7-8] buffer. Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Li, Wang, Dutta et al.: "Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7345-53, 2007 (PubMed).

Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN)", type "Antibodies"
Hosts (55), (15)
Reactivities (69), (32), (28), (16), (15), (12), (12), (2), (2)
Applications (59), (19), (18), (13), (11), (10), (4), (3), (3), (1), (1)
Conjugates (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (10), (3), (3), (2), (2), (2), (1)
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