Der1-Like Domain Family, Member 1 (DERL1) antibody

Details for Product No. ABIN151899
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Antigen
Synonyms
AI195141, AW551338, Derlin-1, 1110021N07Rik, DER-1, DER1, RGD1311835, zgc:55637, wu:fb09d07, wu:fb94d05, wu:fj92g12, derlin-1, DERLIN-1, F17A13.150, F17A13_150, CG10908, Dmel\\CG10908, DDBDRAFT_018813 ... show more
AI195141, AW551338, Derlin-1, 1110021N07Rik, DER-1, DER1, RGD1311835, zgc:55637, wu:fb09d07, wu:fb94d05, wu:fj92g12, derlin-1, DERLIN-1, F17A13.150, F17A13_150, CG10908, Dmel\\CG10908, DDBDRAFT_0188135, DDBDRAFT_0266772, DDB_0188135, DDB_0266772, MGC84200 show less
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(36), (21), (16), (13), (13), (1), (1), (1)
Host
Rabbit
(36), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(23), (16), (14), (10), (4), (2), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN151899
Quantity 0.1 mL
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Immunogen A synthetic peptide made to the C-terminal region of the human Derlin-1 proteinsequence (between residues 200-251).
Specificity This antibody is specific for Derlin-1. Species Reactivity: This antibody reacts with human and canine Derlin-1. No other specie has been tested. The immunogen used for this antibody production has 100% homology with human,Xenopus, bovine, and mouse protein. Localization: Subcellular localization in the endoplasmic reticulum.
Cross-Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
Purification Purified
Alternative Name Derlin-1
Background Derlin-1 is a channel-like protein, found in the ER membrane, responsible for degradingand funneling misfolded proteins and other cellular debris into the appropriatedegradative pathways within the cell. Alternate Names: anti-Degradation in endoplasmic reticulum protein 1 antibody, anti-Der1-like protein 1antibody, anti-DERtrin-1 antibody, anti-DERL1 antibody.
Gene ID 79139
UniProt Q9BUN8
Application Notes Suggested working dilutions: immunohistochemistry 5-10 ug/ml,Western Blot 1:1,000-1:5,000 (ECL). Positive Controls: KRM (canine microsome) lysates. (BD offers commercial liver microsomes)
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Der1-Like Domain Family, Member 1 (DERL1) antibody Detection of Derlin protein in canine KRM microsomes using ABIN151899.
anti-Der1-Like Domain Family, Member 1 (DERL1) antibody (2) Staining of human liver using ABIN151899.
General Huttunen, Guuenette, Peach et al.: "HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation." in: The Journal of biological chemistry, Vol. 282, Issue 38, pp. 28285-95, 2007 (PubMed).

Hosts (36), (1)
Reactivities (36), (21), (16), (13), (13), (1), (1), (1)
Applications (23), (16), (14), (10), (4), (2), (1), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (7), (2), (1), (1), (1)
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