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MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 182-582) antibody

Details for Product No. ABIN151920, Supplier: Log in to see
Antigen
  • wu:faa63d12
  • zgc:64018
  • Mre11
  • Mre11b
  • ATLD
  • HNGS1
  • MRE11
  • MRE11B
Alternatives
anti-Human MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) antibody for Western Blotting
Epitope
AA 182-582
13
13
13
9
6
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
131
68
61
6
4
3
2
2
2
1
1
1
Host
Mouse
124
17
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
110
54
41
23
22
20
11
5
2
1
1
1
Supplier
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Immunogen Amino acids 182-582 of Mre11 expressed in E. coli.
Clone 12D7
Isotype IgG1
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein G purified
Alternative Name MRE11 (MRE11A Antibody Abstract)
Background Mre11 is an 80 kDa protein that acts as a Mn+2 dependent double stranded DNA 3'-5'exonuclease and a single stranded DNA endonuclease. It is part of a larger complexwith Rad50, p95 (nibrin) and possibly other associated proteins involved in the nuclelyticend-processing of double strand breaks and telomere maintenance. Alternate Names: anti-Ataxia-telangiectasia disorder-like antibody, anti-ATLD antibody, anti-MRE11aantibody, anti-MRE11b antibody.
Gene Symbol: MRE11A
Gene ID 4361
Pathways DNA Damage Repair
Application Notes For IHC, incubation with the primary antibody was preceded by microwave treatment of the tissue section for antigen retrieval.
Recommended dilutions: ELISA 1:100-1:2000, Immunocytochemistry/Immunofluorescence 1:1001:200, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:200, Immunoprecipitation 1:100, Western Blot 1:1000-1:2000
Restrictions For Research Use only
Buffer PBS, pH 7.4
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 182-582) antibody (ABIN151920) anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 182-582) antibody
Immunofluorescence (IF) image for anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 182-582) antibody (ABIN151920) anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 182-582) antibody (Image 2)
Product cited in: Zheng, Kanagaraj, Mihaljevic et al.: "MRE11 complex links RECQ5 helicase to sites of DNA damage." in: Nucleic acids research, Vol. 37, Issue 8, pp. 2645-57, 2009 (PubMed).

Helmink, Bredemeyer, Lee et al.: "MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks." in: The Journal of experimental medicine, Vol. 206, Issue 3, pp. 669-79, 2009 (PubMed).

Ottini, Falchetti, Saieva et al.: "MRE11 expression is impaired in gastric cancer with microsatellite instability." in: Carcinogenesis, Vol. 25, Issue 12, pp. 2337-43, 2004 (PubMed).

Giannini, Rinaldi, Ristori et al.: "Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability." in: Oncogene, Vol. 23, Issue 15, pp. 2640-7, 2004 (PubMed).

Limoli, Giedzinski, Bonner et al.: "UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 233-8, 2002 (PubMed).

Background publications Zhong, Chen, Li et al.: "Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 747-50, 1999 (PubMed).

Moreau, Ferguson, Symington: "The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance." in: Molecular and cellular biology, Vol. 19, Issue 1, pp. 556-66, 1999 (PubMed).

Trujillo, Yuan, Lee et al.: "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21447-50, 1998 (PubMed).

Carney, Maser, Olivares et al.: "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response." in: Cell, Vol. 93, Issue 3, pp. 477-86, 1998 (PubMed).