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MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody

Details for Product No. ABIN151920, Supplier: Log in to see
Antigen
  • wu:faa63d12
  • zgc:64018
  • Mre11
  • Mre11b
  • ATLD
  • HNGS1
  • MRE11
  • MRE11B
  • meiotic recombination 11 homolog A (S. cerevisiae)
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • mre11a
  • MRE11A
  • Mre11a
Alternatives
anti-Human MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) antibody for Western Blotting
Reactivity
Human, Mouse (Murine)
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Host
Mouse
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37
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
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3
3
2
2
2
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2
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1
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Application
ELISA, Functional Studies (Func), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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26
22
19
5
5
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4
4
3
1
1
Options
Supplier
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Immunogen Amino acids 182-582 of Mre11 expressed in E. coli.
Clone 12D7
Isotype IgG1
Purification Protein G purified
Alternative Name Mre11 (MRE11A Antibody Abstract)
Background Gene Symbol: MRE11A
Molecular Weight Theoretical MW: 79 kDa
Gene ID 4361
UniProt P49959
Research Area DNA/RNA, Chromatin and Nuclear Signaling
Pathways DNA Damage Repair
Application Notes Western Blot 1:500-1:3000, ELISA 1:100 - 1:2000, Immunohistochemistry 10 - 1:500, Immunocytochemistry/Immunofluorescence 1:100-1:200, Immunoprecipitation, Immunohistochemistry-Paraffin, FunctionalIncubation with the primary antibody was preceded by microwave treatment of the tissue section for antigen retrieval. WB: Predicted molecular weight: 79 kDa.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS ( pH 7.4)
Buffer contains: No Preservative
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody (ABIN151920) anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody
Immunofluorescence (IF) image for anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody (ABIN151920) anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody (Image 2)
Western Blotting (WB) image for anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody (ABIN151920) Western Blot: Mre11 Antibody (12D7) [ABIN151920] - Analysis. A. 30 ug Jurkat whole ce...
Product cited in: Soares, Battistella, Rocca, Matuo, Henriques, Larsen, Escargueil: "Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906." in: The Biochemical journal, Vol. 437, Issue 1, pp. 63-73, 2011 (PubMed). (Sample species: Human). Further details: Western Blotting

Helmink, Bredemeyer, Lee, Huang, Sharma, Walker, Bednarski, Lee, Pandita, Bassing, Sleckman: "MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks." in: The Journal of experimental medicine, Vol. 206, Issue 3, pp. 669-79, 2009 (PubMed).

Zheng, Kanagaraj, Mihaljevic, Schwendener, Sartori, Gerrits, Shevelev, Janscak: "MRE11 complex links RECQ5 helicase to sites of DNA damage." in: Nucleic acids research, Vol. 37, Issue 8, pp. 2645-57, 2009 (PubMed).

Ottini, Falchetti, Saieva, De Marco, Masala, Zanna, Paglierani, Giannini, Gulino, Nesi, Mariani Costantini, Palli: "MRE11 expression is impaired in gastric cancer with microsatellite instability." in: Carcinogenesis, Vol. 25, Issue 12, pp. 2337-43, 2004 (PubMed).

Giannini, Rinaldi, Ristori, Ambrosini, Cerignoli, Viel, Bidoli, Berni, DAmati, Scambia, Frati, Screpanti, Gulino: "Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability." in: Oncogene, Vol. 23, Issue 15, pp. 2640-7, 2004 (PubMed).

Celeste, Fernandez-Capetillo, Kruhlak, Pilch, Staudt, Lee, Bonner, Bonner, Nussenzweig: "Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks." in: Nature cell biology, Vol. 5, Issue 7, pp. 675-9, 2003 (PubMed).

Xu, Stern: "NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8795-803, 2003 (PubMed).

Lukas, Falck, Bartkova, Bartek, Lukas: "Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage." in: Nature cell biology, Vol. 5, Issue 3, pp. 255-60, 2003 (PubMed).

Stewart, Wang, Bignell, Taylor, Elledge: "MDC1 is a mediator of the mammalian DNA damage checkpoint." in: Nature, Vol. 421, Issue 6926, pp. 961-6, 2003 (PubMed).

Lee, Xu, Lee, Ahn, Song, Lee, Canman, Lee, Kastan, Lim: "Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage." in: Molecular cancer research : MCR, Vol. 1, Issue 9, pp. 674-81, 2003 (PubMed).

Xu, Stern: "NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 13, pp. 1842-8, 2003 (PubMed).

Uziel, Lerenthal, Moyal, Andegeko, Mittelman, Shiloh: "Requirement of the MRN complex for ATM activation by DNA damage." in: The EMBO journal, Vol. 22, Issue 20, pp. 5612-21, 2003 (PubMed).

Limoli, Giedzinski, Bonner, Cleaver: "UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 233-8, 2002 (PubMed).

Stracker, Carson, Weitzman: "Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex." in: Nature, Vol. 418, Issue 6895, pp. 348-52, 2002 (PubMed).

Nakanishi, Taniguchi, Ranganathan, New, Moreau, Stotsky, Mathew, Kastan, Weaver, DAndrea: "Interaction of FANCD2 and NBS1 in the DNA damage response." in: Nature cell biology, Vol. 4, Issue 12, pp. 913-20, 2002 (PubMed).

Harfst, Cooper, Neubauer, Distel, Grawunder: "Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome." in: Molecular immunology, Vol. 37, Issue 15, pp. 915-29, 2001 (PubMed). Further details: Western Blotting

Lombard, Guarente: "Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres." in: Cancer research, Vol. 60, Issue 9, pp. 2331-4, 2000 (PubMed).

Wang, Cortez, Yazdi, Neff, Elledge, Qin: "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures." in: Genes & development, Vol. 14, Issue 8, pp. 927-39, 2000 (PubMed).

Gatei, Young, Cerosaletti, Desai-Mehta, Spring, Kozlov, Lavin, Gatti, Concannon, Khanna: "ATM-dependent phosphorylation of nibrin in response to radiation exposure." in: Nature genetics, Vol. 25, Issue 1, pp. 115-9, 2000 (PubMed).

Background publications Moreau, Ferguson, Symington: "The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance." in: Molecular and cellular biology, Vol. 19, Issue 1, pp. 556-66, 1999 (PubMed).