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Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) (AA 1-140) antibody

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Synonyms 5949, CAA61369, CG5949, DNA Pol Delta, Dm Poldelta, Dmel\\CG5949, Poldelta, dnapol delta, l(3)72Ac, Pol delta, POLD3, cdc2, pold, CDC2, CRCS10, POLD, 125kDa
AA 1-140
(10), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(45), (13), (12)
(27), (16), (2)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(41), (9), (7), (6), (6), (4), (4), (3), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Recombinant protein encoding amino acids 1-140 of the large subunit of human DNA polymerase d.
Clone 607
Isotype IgG
Specificity DNA Polymerase delta (607)
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein G purified
Alternative Name POLD1 (POLD1 Antibody Abstract)
Background DNA polymerase d (delta) functions in DNA replication and DNA repair. It alsopossesses 3', to 5', exonuclease activity. In leading strand synthesis itrequires the processivity factor, PCNA. It is also possibly involved in the completion ofDNA synthesis during Okazaki fragment elongation following the initiation of synthesisby the DNA polymerase a/primase complex.
Gene Symbol: POLD1
Gene ID 5424
Pathways Telomere Maintenance, DNA Damage Repair
Application Notes WB: Use at a dilution of 1/1000. Detects a band of approximately 130 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Recommended dilutions: Western Blot 1:1000
Restrictions For Research Use only
Buffer PBS
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) (AA 1-140) antibody (ABIN151923) Detection of human DNA polymerase delta by using anti-pol delta monoclonal antibody [...
Product cited in: Kundu, Balusu, Jaiswal et al.: "Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways." in: Carcinogenesis, Vol. 28, Issue 10, pp. 2089-95, 2007 (PubMed).

Liu, Mo, Rodriguez-Belmonte et al.: "Identification of a fourth subunit of mammalian DNA polymerase delta." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18739-44, 2000 (PubMed).

Background publications Juonsson, Huebscher: "Proliferating cell nuclear antigen: more than a clamp for DNA polymerases." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 19, Issue 11, pp. 967-75, 1998 (PubMed).

Catalog No. ABIN151923
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