Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) antibody

Details for Product No. ABIN151923
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Antigen
Synonyms CDC2, CRCS10, POLD, 125kDa, 5949, CAA61369, CG5949, DNA Pol Delta, Dm Poldelta, Dmel\\CG5949, Poldelta, dnapol delta, l(3)72Ac, Pol delta, POLD3, cdc2, pold
Reactivity
Human
(33), (12), (12)
Host
Mouse
(17), (14), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(32), (9), (4), (4), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN151923
Quantity 0.1 mg
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Immunogen Recombinant protein, corresponding to amino acids 1-140 of the large subunit of HumanDNA Polymerase delta.
Clone LK1
Isotype IgG
Specificity Species Reactivity: Cross-reacts with Human. Not yet tested in other species. Localization: Nuclear.
Cross-Reactivity Human
Purification Purified
Alternative Name POLD1
Background DNA polymerase d (delta) functions in DNA replication and DNA repair. It alsopossesses 3', to 5', exonuclease activity. In leading strand synthesis itrequires the processivity factor, PCNA. It is also possibly involved in the completion ofDNA synthesis during Okazaki fragment elongation following the initiation of synthesisby the DNA polymerase a/primase complex.
Gene ID 5424
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS
Storage 4 °C
Supplier Images
anti-Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) antibody Detection of human DNA polymerase delta by using anti-pol delta monoclonal antibody [607] (ABIN151923) in HeLa whole cell extract.
General Juonsson, Huebscher: "Proliferating cell nuclear antigen: more than a clamp for DNA polymerases." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 19, Issue 11, pp. 967-75, 1998 (PubMed).

Liu, Mo, Rodriguez-Belmonte et al.: "Identification of a fourth subunit of mammalian DNA polymerase delta." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18739-44, 2000 (PubMed).

Kundu, Balusu, Jaiswal et al.: "Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways." in: Carcinogenesis, Vol. 28, Issue 10, pp. 2089-95, 2007 (PubMed).

Hosts (17), (14), (2)
Reactivities (33), (12), (12)
Applications (32), (9), (4), (4), (2), (1), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1), (1), (1), (1)
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