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Details for Product No. ABIN151923

Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) antibody

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Antigen
Synonyms CDC2, CRCS10, POLD, 125kDa, 5949, CAA61369, CG5949, DNA Pol Delta, Dm Poldelta, Dmel\\CG5949, Poldelta, dnapol delta, l(3)72Ac, Pol delta, POLD3, cdc2, pold
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN151923
Quantity 0.1 mg
Price
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Immunogen Recombinant protein, corresponding to amino acids 1-140 of the large subunit of HumanDNA Polymerase delta.
Clone LK1
Isotype IgG
Specificity Species Reactivity: Cross-reacts with Human. Not yet tested in other species. Localization: Nuclear.
Cross-Reactivity Human
Purification Purified
Alternative Name POLD1
Background DNA polymerase d (delta) functions in DNA replication and DNA repair. It alsopossesses 3', to 5', exonuclease activity. In leading strand synthesis itrequires the processivity factor, PCNA. It is also possibly involved in the completion ofDNA synthesis during Okazaki fragment elongation following the initiation of synthesisby the DNA polymerase a/primase complex.
Gene ID 5424
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS
Storage 4 °C
Juonsson, Huebscher: "Proliferating cell nuclear antigen: more than a clamp for DNA polymerases." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 19, Issue 11, pp. 967-75, 1998 (PubMed).

Liu, Mo, Rodriguez-Belmonte et al.: "Identification of a fourth subunit of mammalian DNA polymerase delta." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18739-44, 2000 (PubMed).

Kundu, Balusu, Jaiswal et al.: "Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways." in: Carcinogenesis, Vol. 28, Issue 10, pp. 2089-95, 2007 (PubMed).

Alternatives for antigen "Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1)", type "Antibodies"
Hosts (17), (14), (2)
Reactivities (33), (12), (11)
Applications (32), (7), (4), (4), (3), (2), (2), (1)
Epitopes (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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