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XPC antibody (Xeroderma Pigmentosum, Complementation Group C)

Details for Product anti-XPC Antibody No. ABIN151924, Supplier: Log in to see
Antigen
  • RAD4
  • XP3
  • XPCC
Alternatives
anti-Human XPC antibody for Immunocytochemistry
Reactivity
Human
73
18
14
Host
Mouse
70
8
Clonality (Clone)
Monoclonal ()
Conjugate
This XPC antibody is un-conjugated
7
7
6
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Western Blotting (WB)
53
28
11
11
6
4
3
2
2
2
Supplier
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Immunogen Recombinant XPC purified from E. coli
Clone 3-26
Isotype IgG
Cross-Reactivity (Details) Mouse reactivity reported in scientific literature (PMID: 17229834).
Purification Protein G purified
Alternative Name XPC / XPCC (XPC Antibody Abstract)
Background Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins thathas been shown to be involved in the repair of DNA via the nucleotide excision repair(NER) pathway. Specifically, XPC is believed to be a part of a heteromeric proteincomplex that is involved in the recognition of the DNA lesions during global genomicrepair but not transcription-coupled repair. Alternate Names: anti-DNA repair protein complementing XPC cells antibody, anti-p125 antibody,anti-Xeroderma pigmentosum group C complementing protein antibody, anti-Xerodermapigmentosum group III antibody, anti-XP group C antibody, anti-XP3 antibody, anti-XPCgene antibody, anti-XPCC antibody.
Gene Symbol: XPC
Gene ID 7508
Pathways p53 Signaling, DNA Damage Repair
Application Notes By Western blot, a band is detected at approximately 113 kDa.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:100-1:200, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Paraffin 1:100, Western Blot 1:1000
Restrictions For Research Use only
Buffer PBS [pH 7.2]
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Western blot analysis of human XPC protein using anti-XPC (3.26) monoclonal antibody ...
Immunofluorescence (IF) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) anti-Xeroderma Pigmentosum, Complementation Group C (XPC) antibody (Image 2)
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) anti-Xeroderma Pigmentosum, Complementation Group C (XPC) antibody (Image 3)
Product cited in: Lovejoy, Lock, Yenamandra et al.: "DDB1 maintains genome integrity through regulation of Cdt1." in: Molecular and cellular biology, Vol. 26, Issue 21, pp. 7977-90, 2006 (PubMed).

Background publications de Laat, Jaspers, Hoeijmakers: "Molecular mechanism of nucleotide excision repair." in: Genes & development, Vol. 13, Issue 7, pp. 768-85, 1999 (PubMed).

Aboussekhra, Biggerstaff, Shivji et al.: "Mammalian DNA nucleotide excision repair reconstituted with purified protein components." in: Cell, Vol. 80, Issue 6, pp. 859-68, 1995 (PubMed).