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XPC antibody (Xeroderma Pigmentosum, Complementation Group C)

Details for Product anti-XPC Antibody No. ABIN151924, Supplier: Log in to see
Antigen
  • RAD4
  • XP3
  • XPCC
Alternatives
anti-Human XPC antibody for Immunocytochemistry
Reactivity
Human, Mouse (Murine)
87
27
19
Host
Mouse
72
20
Clonality (Clone)
Monoclonal ()
Conjugate
This XPC antibody is un-conjugated
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7
6
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Western Blotting (WB)
66
29
23
20
17
15
12
3
2
2
Supplier
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Immunogen Recombinant XPC purified from E. coli
Clone 3-26
Isotype IgG1
Cross-Reactivity (Details) Mouse reactivity reported in scientific literature (PMID: 17229834).
Purification Protein G purified
Alternative Name XPC (XPC Antibody Abstract)
Background Gene Symbol: XPC
Gene ID 7508
UniProt Q01831
Pathways p53 Signaling, DNA Damage Repair
Application Notes Western Blot 1:500-1:3000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:100-1:1000, Immunohistochemistry-Paraffin 1:100
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS ( pH 7.2)
Buffer contains: No Preservative
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Western blot analysis of human XPC protein using anti-XPC (3.26) monoclonal antibody ...
Immunofluorescence (IF) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) anti-Xeroderma Pigmentosum, Complementation Group C (XPC) antibody (Image 2)
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) anti-Xeroderma Pigmentosum, Complementation Group C (XPC) antibody (Image 3)
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Western Blot: XPC Antibody (3.26) [ABIN151924] - Whole cell extracts (30 ug) was sepa...
Western Blotting (WB) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Western Blot: XPC Antibody (3.26) [ABIN151924] - HeLa whole cell lysate.
Immunofluorescence (IF) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Immunocytochemistry/Immunofluorescence: XPC Antibody (3.26) [ABIN151924] - HeLa cells...
Immunofluorescence (IF) image for anti-XPC antibody (Xeroderma Pigmentosum, Complementation Group C) (ABIN151924) Immunocytochemistry/Immunofluorescence: XPC Antibody (3.26) [ABIN151924] - Analysis o...
Product cited in: Beresova, Vesela, Chamrad, Voller, Yamada, Furst, Lenobel, Chroma, Gursky, Krizova, Mistrik, Bartek: "Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics." in: Journal of proteome research, Vol. 15, Issue 12, pp. 4505-4517, 2016 (PubMed).

Berra, de Oliveira, Garcia, Rocha, Lerner, Lima, Baptista, Menck: "Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue." in: Free radical biology & medicine, Vol. 61, pp. 343-56, 2014 (PubMed). (Sample species: Human). Further details: Western Blotting

Mohni, Kavanaugh, Cortez: "ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency." in: Cancer research, Vol. 74, Issue 10, pp. 2835-45, 2014 (PubMed). (Sample species: Human). Further details: Western Blotting

Kothandapani, Gopalakrishnan, Kahali, Reisman, Patrick: "Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity." in: Experimental cell research, Vol. 318, Issue 16, pp. 1973-86, 2012 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Muenyi, States, Masters, Fan, Helm, States et al.: "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal ..." in: Journal of ovarian research, Vol. 4, pp. 9, 2011 (PubMed). (Sample species: Human). Further details: Western Blotting

Takedachi, Saijo, Tanaka: "DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA." in: Molecular and cellular biology, Vol. 30, Issue 11, pp. 2708-23, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Acu, Liu, Suino-Powell, Mooney, DAssoro, Rowland, Muotri, Correa, Niu, Kumar, Salisbury: "Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells." in: Cancer research, Vol. 70, Issue 8, pp. 3320-8, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

de Feraudy, Ridd, Richards, Kwok, Revet, Oh, Feeney, Cleaver: "The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas." in: The American journal of pathology, Vol. 177, Issue 2, pp. 555-62, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Rezvani, Mahfouf, Ali, Chemin, Ged, Kim, de Verneuil, Taïeb, Bickers, Mazurier: "Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes." in: Nucleic acids research, Vol. 38, Issue 3, pp. 797-809, 2010 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Klein, Nigg: "SUMO-dependent regulation of centrin-2." in: Journal of cell science, Vol. 122, Issue Pt 18, pp. 3312-21, 2009 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Yan, Seo, Kinsella: "Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 22, pp. 6912-20, 2009 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Ferguson-Yates, Li, Dong, Hsiao, Oh: "Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63." in: Carcinogenesis, Vol. 29, Issue 1, pp. 70-5, 2008 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Wang, Liu, Matsuda, Plunkett: "Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair." in: Cancer research, Vol. 68, Issue 10, pp. 3881-9, 2008 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Laposa, Huang, Cleaver: "Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 4, pp. 1389-94, 2007 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Lovejoy, Lock, Yenamandra, Cortez: "DDB1 maintains genome integrity through regulation of Cdt1." in: Molecular and cellular biology, Vol. 26, Issue 21, pp. 7977-90, 2006 (PubMed).

Ferguson, Oh: "Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53." in: Cancer research, Vol. 65, Issue 19, pp. 8723-9, 2005 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Background publications de Laat, Jaspers, Hoeijmakers: "Molecular mechanism of nucleotide excision repair." in: Genes & development, Vol. 13, Issue 7, pp. 768-85, 1999 (PubMed).

Aboussekhra, Biggerstaff, Shivji, Vilpo, Moncollin, Podust, Protić, Hübscher, Egly, Wood: "Mammalian DNA nucleotide excision repair reconstituted with purified protein components." in: Cell, Vol. 80, Issue 6, pp. 859-68, 1995 (PubMed).