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Details for Product No. ABIN151937

PTEN Induced Putative Kinase 1 (PINK1) antibody

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Antigen
Synonyms BRPK, PARK6, BEST:GH23468, CG4523, Dmel\\CG4523, PINK, PINK1, dPINK1, dPink1, pink1, AU042772, AW557854, mFLJ00387, 1190006F07Rik, wu:fc39e12, zgc:101729
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151937
Quantity 0.1 mL
Price
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Immunogen An N-terminal region synthetic peptide made to the human Pink1 protein sequence(between residues 1-50).
Specificity Species Reactivity: Reacts with human and mouse. Localization: Mitochondrion.
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name PINK1
Background Phosphatase and Tensin Homolog (PTEN) dephosphorylates lipids. Malfunctions in thiscontribute to many human cancers. PTEN induced putative kinase 1 (Pink1) was firstdiscovered when researching the PTEN signaling pathway, thus Pink1 is also involvedin many human cancers. It is found in the mitochondria and its homozygousC-terminus mutation has been implicated in the early development of Parkinson'sdisease. Alternate Names: anti-Pink1 antibody, anti-PARK6 antibody, anti-BRPK antibody, anti-PTEN-inducedputative kinase protein 1 antibody, anti-Serine/threonin-protein kinase PINK1mitochondria [precursor] antibody.
Gene ID 65018, 68943
UniProt Q9BXM7
Research Area Signaling, Metabolism
Application Notes Suggested working dilutions: Western Blot - 1:500
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate, [pH7-8]. Preservative: 0.1% Sodium azide.
Preservative Sodium azide
Storage 4 °C
Meijer, Karimi-Busheri, Huang et al.: "Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe." in: The Journal of biological chemistry, Vol. 277, Issue 6, pp. 4050-5, 2002 (PubMed).

Exner, Treske, Paquet et al.: "Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 45, pp. 12413-8, 2007 (PubMed).

Alternatives for antigen "PTEN Induced Putative Kinase 1 (PINK1)", type "Antibodies"
Hosts (69), (28), (6)
Reactivities (82), (54), (27), (4), (1)
Applications (97), (32), (27), (21), (11), (2), (2), (1), (1), (1)
Conjugates (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (26), (20), (18), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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