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PTEN Induced Putative Kinase 1 (PINK1) antibody

Antigen

PTEN Induced Putative Kinase 1 (PINK1)
Synonyms BRPK, PARK6, FLJ27236, BEST:GH23468, PINK1, dPINK1, DmelCG4523, CG4523, AU042772, AW557854, mFLJ00387, 1190006F07Rik, MGC189438, wu:fc39e12, zgc:101729
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN151937
Quantity 0.1 ml  (1 mg/ml)  (Variants)
Price Product not available in this region.
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anti-PTEN Induced Putative Kinase 1 (PINK1) antibody

Additional Information
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Alternative name PINK1
Gene ID 65018, 68943
UniProt Q9BXM7
Immunogen An N-terminal region synthetic peptide made to the human Pink1 protein sequence(between residues 1-50).
Cross-Reactivity Human, Mouse (Murine)
Description Phosphatase and Tensin Homolog (PTEN) dephosphorylates lipids. Malfunctions in thiscontribute to many human cancers. PTEN induced putative kinase 1 (Pink1) was firstdiscovered when researching the PTEN signaling pathway, thus Pink1 is also involvedin many human cancers. It is found in the mitochondria and its homozygousC-terminus mutation has been implicated in the early development of Parkinson'sdisease. Alternate Names: anti-Pink1 antibody, anti-PARK6 antibody, anti-BRPK antibody, anti-PTEN-inducedputative kinase protein 1 antibody, anti-Serine/threonin-protein kinase PINK1mitochondria [precursor] antibody.
Specificity Species Reactivity: Reacts with human and mouse. Localization: Mitochondrion.

Application Details
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Application Notes Suggested working dilutions: Western Blot - 1:500
Concentration 1 mg/ml
Purification Aff - Purified
Buffer Tris-citrate/phosphate, [pH7-8]. Preservative: 0.1% Sodium azide.
Storage Store at 4C. Do not freeze.
Research Area Signaling, Metabolism
Restrictions For Research Use only

Publications
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Meijer, Karimi-Busheri, Huang et al.: "Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe." in: The Journal of biological chemistry, Vol. 277, Issue 6, pp. 4050-5, 2002 (PubMed).

Exner, Treske, Paquet et al.: "Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 45, pp. 12413-8, 2007 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "PTEN Induced Putative Kinase 1 (PINK1)", type "Antibodies"
Hosts Rabbit (38), Mouse (6), Goat (4)
Reactivities Human (33), Mouse (Murine) (13), Rat (Rattus) (7), Fruit Fly (Drosophila melanogaster) (4), Hamster (1)
Applications Western Blotting (WB) (43), ELISA (26), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunocytochemistry (ICC) (1), Immunoprecipitation (IP) (1)
Epitopes N-Term (9), C-Term (6), AA 258-274 (5), Internal Region (3), AA 484-504 (2), AA 1-18 (1), AA 175-250 (1), Center (1), N-Term,Thr133 (1)