Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222), (AA 217-226) antibody

Details for Product No. ABIN151945
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Antigen
Synonyms FANCD2, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, xfancd2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, 2410150O07Rik, AU015151, BB137857
Epitope
pSer222, AA 217-226
(23), (12), (10), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(92), (55), (46), (36), (24), (24), (6)
Host
Rabbit
(87), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB)
(62), (33), (30), (25), (23), (16), (12), (10), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.2 mL
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Catalog No. ABIN151945
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Immunogen A synthetic peptide made to human FANCD2 (residues 217-226), surrounding the phosphorylated Serine 222.
Purification Whole antisera
Alternative Name FANCD2
Background Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disordercharacterized by congenital defects, progressive bone marrow failure, and cellularhypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellularresistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation.DNA damage activates the monoubiquitination of FANCD2, targeting nuclear focicontaining the BRCA1 protein. Alternate Names: anti-FA4 antibody, anti-FACD antibody, anti-FAD antibody, anti-FAD2 antibody,anti-FANCD antibody, anti-FANCONI ANEMIA COMPLEMENTATION GROUP Dantibody, anti-FANCONI PANCYTOPENIA TYPE 4 antibody, anti-phosphorylatedFANCD2 antibody, anti-phosphospecific FANCD2 antibody, anti-phosphorylatedFanconi anemia antibody.
Gene Symbol: FANCD2
Gene ID 2177
UniProt Q9BXW9
Application Notes This FANCD2 [p Ser222] antibody is useful for Western Blot. 1:400 dilution recommended for PD20 FANCD2 overexpressing cells, 1:100 for HeLa cells, 1:200 for other cell types.
Recommended dilutions: Western Blot 1:100-1:500
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Supplier Images
anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222), (AA 217-226) antibody anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222), (AA 217-226) antibody
anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222), (AA 217-226) antibody (2) Indicated lymphoblasts (PD7, WT: GM1526, AT) were irradiated with 15 Gy (2), and immunoblotted with anti-FANCD2 and anti-FANCD2 (pS-222), cat# ABIN151945.
General Taniguchi, Garcia-Higuera, Xu et al.: "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways." in: Cell, Vol. 109, Issue 4, pp. 459-72, 2002 (PubMed).

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