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Antibodies
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anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody
Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody
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| Synonyms |
FANCD2, CG31192, CG31194, dmFANCD2, Dmel\CG17269, CG17269, FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, fancd2 |
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Binding Site
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Conjugate
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2)
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Application
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| Catalog no. |
ABIN151945 |
| Quantity |
0.2 ml |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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FANCD2
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Gene ID
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2177
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Immunogen
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A synthetic peptide made to the human FANCD2 sequence (residues 217-226),surrounding a phosphorylated serine (222).
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Cross-Reactivity
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Human
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Format
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Serum
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Description
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Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disordercharacterized by congenital defects, progressive bone marrow failure, and cellularhypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellularresistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation.DNA damage activates the monoubiquitination of FANCD2, targeting nuclear focicontaining the BRCA1 protein. Alternate Names: anti-FA4 antibody, anti-FACD antibody, anti-FAD antibody, anti-FAD2 antibody,anti-FANCD antibody, anti-FANCONI ANEMIA COMPLEMENTATION GROUP Dantibody, anti-FANCONI PANCYTOPENIA TYPE 4 antibody, anti-phosphorylatedFANCD2 antibody, anti-phosphospecific FANCD2 antibody, anti-phosphorylatedFanconi anemia antibody.
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Specificity
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This antibody is specific for the phosphorylated form of FANCD2.Phosphorylated:Ser222. Species Reactivity: Human. Localization: Nuclear.
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Application Notes
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Suggested working dilutions: Western Blot 1:400 for PD20 FANCD2 overexpressing cells, 1:100 for HeLa cells, 1:200, For other cell types
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Purification
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Serum
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Buffer
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0.2 ml of whole rabbit antisera. Contains no preservative.
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Storage
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Taniguchi, Garcia-Higuera, Xu et al.: "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways." in: Cell, Vol. 109, Issue 4, pp. 459-72, 2002 (PubMed).
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Alternatives for antigen "Fanconi Anemia, Complementation Group D2 (FANCD2)", type "Antibodies"
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Hosts
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Rabbit (54), Mouse (7)
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Reactivities
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Human (61), Mouse (Murine) (44), Rat (Rattus) (42), Cow (Bovine) (37), Dog (Canine) (37), Pig (Porcine) (18), Cat (Feline) (1), Chicken (1)
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Applications
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Immunofluorescence (IF) (33), Western Blotting (WB) (26), ELISA (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), Immunohistochemistry (IHC) (11), Immunoprecipitation (IP) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunoelectron Microscopy (IEM) (2)
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Conjugates
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2)
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Epitopes
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pSer222 (22), Isoform B (1), Isoform B,ubiquitinated (1), N-Term (1)
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Alternatives 
