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Details for Product No. ABIN151945

Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody

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Antigen
Synonyms FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, FAD2, FANCD2, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, xfancd2
Epitope
»Alternatives pSer222
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN151945
Quantity 0.2 mL
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Immunogen A synthetic peptide made to the human FANCD2 sequence (residues 217-226),surrounding a phosphorylated serine (222).
Specificity This antibody is specific for the phosphorylated form of FANCD2.Phosphorylated:Ser222. Species Reactivity: Human. Localization: Nuclear.
Cross-Reactivity Human
Purification Serum
Alternative Name FANCD2
Background Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disordercharacterized by congenital defects, progressive bone marrow failure, and cellularhypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellularresistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation.DNA damage activates the monoubiquitination of FANCD2, targeting nuclear focicontaining the BRCA1 protein. Alternate Names: anti-FA4 antibody, anti-FACD antibody, anti-FAD antibody, anti-FAD2 antibody,anti-FANCD antibody, anti-FANCONI ANEMIA COMPLEMENTATION GROUP Dantibody, anti-FANCONI PANCYTOPENIA TYPE 4 antibody, anti-phosphorylatedFANCD2 antibody, anti-phosphospecific FANCD2 antibody, anti-phosphorylatedFanconi anemia antibody.
Gene ID 2177
Application Notes Suggested working dilutions: Western Blot 1:400 for PD20 FANCD2 overexpressing cells, 1:100 for HeLa cells, 1:200, For other cell types
Restrictions For Research Use only
Format Liquid
Buffer 0.2 ml of whole rabbit antisera. Contains no preservative.
Preservative Without preservative
Storage -20 °C
Taniguchi, Garcia-Higuera, Xu et al.: "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways." in: Cell, Vol. 109, Issue 4, pp. 459-72, 2002 (PubMed).

Alternatives for antigen "Fanconi Anemia, Complementation Group D2 (FANCD2)", type "Antibodies"
Hosts (85), (17)
Reactivities (96), (51), (41), (36), (24), (24), (3), (3), (2)
Applications (67), (32), (30), (30), (23), (21), (16), (5), (2), (2), (1)
Conjugates (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (21), (12), (8), (2), (2), (1), (1)
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