Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody

Details for Product No. ABIN151945
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Antigen
Synonyms FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, FAD2, FANCD2, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, xfancd2
Epitope
pSer222
(23), (12), (9), (2), (2), (1), (1), (1)
Reactivity
Human
(91), (53), (44), (36), (24), (24), (3)
Host
Rabbit
(80), (17)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB)
(62), (31), (30), (30), (23), (15), (10), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN151945
Quantity 0.2 mL
Price
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Immunogen A synthetic peptide made to the human FANCD2 sequence (residues 217-226),surrounding a phosphorylated serine (222).
Specificity This antibody is specific for the phosphorylated form of FANCD2.Phosphorylated:Ser222. Species Reactivity: Human. Localization: Nuclear.
Cross-Reactivity Human
Purification Serum
Alternative Name FANCD2
Background Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disordercharacterized by congenital defects, progressive bone marrow failure, and cellularhypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellularresistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation.DNA damage activates the monoubiquitination of FANCD2, targeting nuclear focicontaining the BRCA1 protein. Alternate Names: anti-FA4 antibody, anti-FACD antibody, anti-FAD antibody, anti-FAD2 antibody,anti-FANCD antibody, anti-FANCONI ANEMIA COMPLEMENTATION GROUP Dantibody, anti-FANCONI PANCYTOPENIA TYPE 4 antibody, anti-phosphorylatedFANCD2 antibody, anti-phosphospecific FANCD2 antibody, anti-phosphorylatedFanconi anemia antibody.
Gene ID 2177
Application Notes Suggested working dilutions: Western Blot 1:400 for PD20 FANCD2 overexpressing cells, 1:100 for HeLa cells, 1:200, For other cell types
Restrictions For Research Use only
Format Liquid
Buffer 0.2 ml of whole rabbit antisera. Contains no preservative.
Preservative Without preservative
Storage -20 °C
Supplier Images
anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody
anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (pSer222) antibody (2) Indicated lymphoblasts (PD7, WT: GM1526, AT) were irradiated with 15 Gy (2), and immunoblotted with anti-FANCD2 and anti-FANCD2 (pS-222), cat# ABIN151945.
General Taniguchi, Garcia-Higuera, Xu et al.: "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways." in: Cell, Vol. 109, Issue 4, pp. 459-72, 2002 (PubMed).

Hosts (80), (17)
Reactivities (91), (53), (44), (36), (24), (24), (3)
Applications (62), (31), (30), (30), (23), (15), (10), (2), (1), (1), (1), (1)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Epitopes (23), (12), (9), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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