VEGFR-1/2 (Haemangioblast and Stem Cell Marker) antibody

Details for Product No. ABIN151960
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Antigen
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Flow Cytometry (FACS), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN151960
Quantity 0.1 mL
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Immunogen A synthetic peptide made to an internal region of the murine VEGFR1 protein sequence(between residues 800-900). There is 87% identity between the immunogen used forthis production and the VEGFR-2 protein.
Specificity This antibody is specific for VEGFR-1 with significant cross-reactivity with the VEGFR-2protein. Species Reactivity: This antibody reacts with human protein. Other species have not yet been tested. Theimmunogen used for this antibody production has 100% homology with mouse, rat andhuman VEGFR-1 proteins. Localization: Type 1 membrane protein (isoform Flt1).
Background Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. TheVEGF-kinase ligand/receptor signaling system plays a key role in vascular developmentand regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, arethought to be important for the development of embryonic vasculature. It has beenshown that an alternately spliced form of FLT1 produces a soluble protein, termedsFLT1, which binds vascular endothelial growth factor with high affinity, playing aninhibitory role in angiogenesis. Alternate Names: anti-VEGFR1 antibody, anti-VEGFR 1 antibody, anti-Vascular permeability factorreceptor antibody, anti-Tyrosine-protein kinase receptor FLT antibody, anti-Flt-1antibody, anti-Tyrosine-protein kinase FRT antibody, anti-Fms-like tyrosine kinase 1antibody, anti-Embryonic receptor kinase 2 antibody, anti-VEGFR2 antibody,anti-VEGFR 2 antibody, anti-Protein-tyrosine kinase receptor flk-1 antibody, anti-Fetalliver kinase 1 antibody, anti-Kinase NYK antibody, anti-FLK1 antibody, anti-KDRantibody, anti-Kinase insert domain receptor antibody, anti-KRD1 antibody, anti-Ly73antibody, anti-Protein tyrosine kinase receptor FLK1 antibody, anti-Vascular endothelialgrowth factor receptor 2 antibody.
Gene ID 2321
Application Notes Suggested working dilutions: Western Blot 1:250-1:1,000. Positive Controls: HUVEC lysate
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-VEGFR-1/2 (Haemangioblast and Stem Cell Marker) antibody Chimeric CSF-1R/VEGFR-2 detection in transfected lysates.
General Rahimi, Dayanir, Lashkari: "Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16986-92, 2000 (PubMed).

Gluzman-Poltorak, Cohen, Shibuya et al.: "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 18688-94, 2001 (PubMed).

Takahashi, Hattori, Iwamatsu et al.: "A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46304-14, 2004 (PubMed).

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