WAPL (Human) antibody

Overview

Antigen	WAPL
Immunogen	A synthetic peptide which maps to a region between residues 1125 and 1175 of humanwings apart like/KIAA0261 using the numbering given in TrEMBL entry Q7Z5K2(GeneID 23063).
Reactivity	Human, Mouse (Murine)
Antibody Type	Polyclonal
Format	Aff - Purified
Description	The hWAPL mRNA was predominantly expressed in uterine cervical cancer, with weakexpression in all other normal and tumor tissues examined. hWAPL expression inbenign epithelia was confined to the basal cell layers, whereas in dysplasias itincreasingly appeared in more superficial cell layers and showed a significant correlationwith severity of dysplasia. Diffuse hWAPL expression was found in all invasivesquamous cell carcinomas examined. These results demonstrate that hWAPL isassociated with cell growth, and the hWAPL expression may play a significant role incervical carcinogenesis and tumor progression. Synonyms: WAPL antibody, hWAPL antibody, human homolog of wings apart like protein antibody,FOE antibodyfriend of EBNA2 antibody, KIAA0261 antibody
Host	Rabbit
Specificity	NB 100-552 is specific for human WAPL protein. Human. Other species not tested. Reactivity with mouse WAPL is expected owing tocomplete identity between this ortholog and human WAPL at the site to which theepitope maps.

Application	Western Blotting (WB)
Application Notes	Optimal working dilutions should be determined experimentally by the investigator.Prepare working dilution immediately before use. Suggested starting dilutions are as follows. Western Blot: 1:2,500 – 1:10,000 Immunoprecipitation: not tested Histo/Cytochemistry: not tested*In some cases, the antibody may be diluted further than indicated. Positive Control:HeLa nuclear extract (NB 800-PC9)
Concentration	1 mg/ml
Buffer	0.1 ml of affinity purified rabbit sera in a Tris-citrate/phosphate (pH 7-8) buffer with 0.1%sodium azide.
Storage	Store at 4 degrees Celcius.
Restrictions	For Research Use only

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