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Details for Product No. ABIN152048

E1A Binding Protein P300 (EP300) antibody

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Synonyms KAT3B, RSTS2, p300, A430090G16, A730011L11, p300 HAT
»Alternatives Human, Monkey, Mouse (Murine), Rat (Rattus), Mustelid
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152048
Quantity 0.2 mL
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Immunogen Fusion protein containing residues 1572-2371 of human p300.
Clone RW109
Isotype IgG1
Specificity This antibody is specific for p300 protein. This antibody recognizes residues2107-2283. Species Reactivity: Human, mouse, rat, monkey, and mink. Localization: Nuclear.
Cross-Reactivity Human, Monkey, Mouse (Murine), Rat (Rattus)
Purification Ascites
Alternative Name EP300 / P300
Background P300 is a relatively stable, ubiquitously expressed, nuclear phosphoprotein which isconserved among a variety of mammalian species. It is actively synthesized andphosphorylated in both quiescent and proliferating cells.Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) andp300 are closely related transcriptional coactivators and have been shown to directlyinteract with many different DNA-binding transcription factors including nuclear hormonereceptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP andp300 have been shown to display histone acetyltransferase (HAT) activity, capable ofacetylating all four core histone particles in nucleosomes. As a result of HAT activity, ithas been suggested CBP and p300 may play a direct role in activating chromatin fortranscription. Alternate Names: anti-CREBBP/EP300 inhibitory protein 1 antibody, anti-Cyclic AMP responsive enhancerbinding protein antibody, anti-EP300: E1A binding protein p300 antibody, anti-RB andP300 binding protein EID 1 antibody, anti-Retinoblastoma protein associated proteinantibody.
Gene ID 2033, 328572, 170915
Application Notes Suggested working dilutions: Western Blot 1:1,000
Restrictions For Research Use only
Format Liquid
Concentration 8.2 mg/ml
Buffer Raw ascites
Storage -20 °C
Eckner, Ewen, Newsome et al.: "Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor." in: Genes & development, Vol. 8, Issue 8, pp. 869-84, 1994 (PubMed).

Eckner, Ludlow, Lill et al.: "Association of p300 and CBP with simian virus 40 large T antigen." in: Molecular and cellular biology, Vol. 16, Issue 7, pp. 3454-64, 1996 (PubMed).

Eckner, Yao, Oldread et al.: "Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation." in: Genes & development, Vol. 10, Issue 19, pp. 2478-90, 1996 (PubMed).

Alternatives for antigen "E1A Binding Protein P300 (EP300)", type "Antibodies"
Hosts (98), (67)
Reactivities (162), (81), (81), (48), (48), (36), (24), (24), (20), (5), (4)
Applications (90), (53), (48), (44), (40), (40), (16), (14), (9), (1), (1), (1)
Conjugates (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2)
Epitopes (21), (19), (15), (9), (5), (4), (4), (1), (1), (1), (1)