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Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Antigen

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
Synonyms Flk1, Ly73, Flk-1, Krd-1, VEGFR2, VEGFR-2, sVEGFR-2, 6130401C07, FLK1, CD309, VEGFR, Vegfr-2, MGC93590, KDR, FLK-1, flk-1, vegfr-2
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunoprecipitation (IP), Western Blotting (WB)
2 references available
Catalog no. ABIN152058
Quantity 0.1 ml  (Variants)
Price Product not available in this region.
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anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Additional Information
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Alternative name CD309 / VEGFR-2 / Flk-1
Gene ID 3791, 3791
Immunogen This antibody was made to residues corresponding to the kinase insert or C-terminus ofmurine VEGFR-2 (residues 1158-1365).
Cross-Reactivity Human, Mouse (Murine)
Description VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activationplays an essential role in a large number of biological processes such as embryonicdevelopment, wound healing, cell proliferation, migration and differentiation. Like othergrowth factor receptors, upon ligand binding VEGF receptor 2 dimerises and isautophosphorylated on multiple tyrosine residues. These sites can be involved in theregulation of kinase activity or serve as binding sites for SH2 and phosphotyrosinebinding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 inthe activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosinekinase activity. Alternate Names: anti-VEGFR2 antibody, anti-VEGFR 2 antibody, anti-Protein-tyrosine kinase receptorflk-1 antibody, anti-Fetal liver kinase 1 antibody, anti-Kinase NYK antibody, anti-FLK1antibody, anti-KDR antibody, anti-Kinase insert domain receptor antibody, anti-KRD1antibody, anti-Ly73 antibody, anti-Protein tyrosine kinase receptor FLK1 antibody,anti-Vascular endothelial growth factor receptor 2 antibody.
Specificity This antibody is specific for VEGFR-2. Species Reactivity: This antibody reacts with mouse and human VEGFR-2 proteins. Other species havenot been tested.

Application Details
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Application Notes Suggested working dilutions: immunoprecipitation 2-5 ul,Western Blot 1:2,000-1:10,000
Purification Aff - Purified
Buffer Preservative: Sodium Azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Research Area Cytokines, Receptors
Restrictions For Research Use only

Publications
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Rahimi, Dayanir, Lashkari: "Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16986-92, 2000 (PubMed).

Meyer, Singh, Rahimi: "The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 735-42, 2003 (PubMed).

Alternatives
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Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts Rabbit (199), Mouse (33), Rat (16), Escherichia Coli (E. coli) (2), Goat (2), Chicken (1)
Reactivities Human (204), Mouse (Murine) (110), Rat (Rattus) (79), Dog (Canine) (20), Chicken (19), Cow (Bovine) (19), Pig (Porcine) (18), Cat (Feline) (1)
Applications Western Blotting (WB) (167), Immunohistochemistry (IHC) (89), ELISA (85), Immunofluorescence (IF) (71), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (61), Flow Cytometry (FACS) (57), Immunoprecipitation (IP) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Neutralization (Neut) (5), Functional Studies (Func) (3), Immunocytochemistry (ICC) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (14), PE (4), APC (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), FITC (2), PE,Cy5.5 (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), E-Tag (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr951 (20), C-Term (18), pTyr1175 (15), pTyr1214 (13), Internal Region (5), pTyr996 (4), N-Term (3), Tyr1175 (3), Tyr1214 (3), Tyr951 (3), pTyr1054 (3), pTyr1059 (3), AA 1158-1345 (2), pY1054 (2), AA 1057-1061 (1), AA 20-762 (1), AA 20-764 (1), Extracellular Domain (1), Extracellular,AA 20-764 (1), pTyr1054, pTyr1059 (1), pY951 (1)