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Details for Product No. ABIN152088

Vascular Endothelial Growth Factor A (VEGFA) antibody

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Antigen
Synonyms MVCD1, VEGF, VPF, Vpf, Vegf, Vegf120, Vegf164, Vegf188, VEGF-A, VEGF164, eVEGF120, eVEGF164, vegf, vegfa, wu:fj82c06, vegf-a, vpf, vefg
Reactivity
»Alternatives Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN152088
Quantity 0.1 mg
Price
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Immunogen BALB/C mice were injected with a recombinant VEGF protein.
Clone VG1
Isotype IgG1
Specificity This antibody is specific to a cluster of proteins between 19 and 22kD (reduced). VEGF (Vascular Endothelial Growth Factor) is a homodimeric disulfide-linkedglycoprotein involved in angiogenesis, which promotes tumor progression andmetastasis. Species Reactivity: Human, Mouse, Rat, and Dog. Not tested in other species.
Purification Purified
Alternative Name VEGF-A
Background VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linkedglycoprotein involved in angiogenesis which promotes tumor progression andmetastasis. It exhibits potent mitogenic and permeability inducing properties specific forthe vascular endothelium. Of the four isoforms of VEGF, the smaller two, VEGF 165 andVEGF 121, are secreted proteins and act as diffusible agents, whereas the larger two(VEGF 189 and VEGF 206) remain cell associated. Alternate Names: anti-Vascular Endothelial Growth Factor antibody, anti-Vascular Permeability Factorantibody, anti-VEGFA antibody, anti-VPF antibody.
Gene ID 7422, 22339, 83785
UniProt Q00731
Research Area Cytokines, Growth Factors, Receptors, Immunology, Inflammation, Signaling
Application Notes IHC: Diluted to a titer of 1:20-1:50 in an ABC method. However, depending on thestaining conditions employed, we suggest that the final dilution should be determined by the user. We suggest an incubation period of 30-60 minutes at room temperature. High temperature treatment of formalin-fixed tissue sections using 1mM EDTA, pH 8.0must be performed prior to the immunostaining. Positive Controls: Corpus luteum, astrocytoma or hemoangiosarcoma
Restrictions For Research Use only
Concentration 1.2 mg/ml
Buffer PBS. Preservative: No Preservative.
Storage 4 °C
Turley, Scott, Watts et al.: "Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1." in: The Journal of pathology, Vol. 186, Issue 3, pp. 313-8, 1999 (PubMed).

Giatromanolaki, Koukourakis, Sivridis et al.: "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer." in: The Journal of pathology, Vol. 200, Issue 2, pp. 222-8, 2003 (PubMed).

Ptaszynska, Pendrak, Bandle et al.: "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." in: Molecular cancer research : MCR, Vol. 6, Issue 3, pp. 352-63, 2008 (PubMed).

Alternatives for antigen "Vascular Endothelial Growth Factor A (VEGFA)", type "Antibodies"
Hosts (268), (109), (20), (5), (4), (3)
Reactivities (316), (126), (111), (65), (64), (62), (43), (35), (5), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Applications (305), (202), (108), (64), (49), (31), (24), (19), (17), (12), (10), (9), (8), (8), (4), (3), (2), (2), (2), (2), (1), (1)
Conjugates (36), (10), (8), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (1), (1), (1), (1)
Epitopes (30), (14), (7), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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